摘要
目的了解粤北中老年人群葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症发生情况,为患该病患者的防治提供参考依据。方法选取2017年9月～2018年9月在我院就诊粤北地区(连州市、连山壮族瑶族自治县、连南瑶族自治县、阳山县)45岁以上患者,应用G6PD活性检测对G6PD缺乏患者进行筛查,了解粤北中老年人群G6PD缺乏症发生情况。结果 4731例粤北地区中老年人群中,共有345例发生G6PD缺乏症,占7.29%,其中男228(4.82%)例,女117(2.47%)例,男、女性均以连山壮族瑶族自治县发生率最高,分别达10.19%、6.56%;在45～59岁年龄区间中,男、女阳性率最高为连山壮族瑶族自治县、连州市,分别为10.87%,7.05%,60岁以上男、女阳性率最高为连山壮族瑶族自治县,分别为9.68%,7.69%,45～59岁总阳性率为7.72%,60岁以上总阳性率为7.07%;在粤北不同地区中老年人群G6PD活性上,连山连南瑶族自治县显著比其他地区低,差异有统计学意义(P <0.05)。结论粤北中老年人群G6PD缺乏现象较普遍,尤其是连山壮族瑶族自治县地区等少数民族聚集地区,应加强G6PD缺乏症的筛查,可预防和避免溶血性疾病的发生和发展。
Objective To investigate the G6PD (Glucose-6-phosphate dehydrogenase) deficiency and provide the clinical treatment basis for middle-aged and elderly people in the northern Guangdong areas. Methods From September 2017 to September 2018,patients over 45 years old in northern Guangdongareas (Lianzhou city,Zhuang?Yao Autonomous County of Lianshan,Yao Autonomous County of Liannan,Yangshan County) were screened for G6PD deficiency by G6PD activity test to understand the prevalence of G6PD deficiency among middle-aged and elderly people in northern Guangdong. Results Among the 4731 middle-aged populations in northern Guangdong,345 cases had G6PD deficiency,accounting for 7.29%,including 228 (4.82%) males and 117 females (2.47%).The male and female ratio of G6PD deficiency in Zhuang-Yao Autonomous County of Lianshan was 10.19% and 6.56%.The male and female positive rate in Zhuang-Yao Autonomous County of Lianshan, Lianzhou was 10.87% and 7.05% among patients aged 45-59,patients over 60 years old at 9.68% and 7.69%.The overall positive rate was 7.72% among patients aged 45-59 and 7.07% among patients over 60 years old;In the G6PD activity of the old population in different areas of northern Guangdong,Lianshan Liannan Yao Autonomous County was significantly lower than other areas (P < 0.05). Conclusion G6PD deficiency is common among middle-aged and elderly people in northern Guangdong,especially in ethnic minority areas such as Lianshan Zhuang and Yao Autonomous County.Thus the screening of G6PD deficiency is good to prevent the genesis and development of hemolytic disease.
作者
陈荣平
吴涓涓
邓家艳
奉继运
温节喆
CHEN Rongping;WU Juanjuan;DENG Jiayan;FENG Jiyun;WEN Jiezhe(Department of Neurology,Lianzhou People’s Hospital,Guangdong Province,Lianzhou 513400,China)
出处
《中国医药科学》
2019年第9期9-11,15,共4页
China Medicine And Pharmacy
基金
广东省清远市科技计划项目(170815171900562)
关键词
葡萄糖-6-磷酸脱氢酶缺乏症
活性检测
粤北
筛查
Glucose-6-phosphate dehydrogenase deficiency
Activity assay
Northern Guangdong
Screening
