摘要
目的对比观察凉血通瘀方与普瑞巴林治疗慢性每日头痛的有效性及安全性。方法选取我院2015年9月～2017年9月收治的慢性每日头痛患者共80例,按照随机数字表法分为对照组(n=39)与观察组(n=41),对照组患者接受普瑞巴林口服治疗,观察组接受凉血通瘀方治疗,治疗周期均为60d。比较两组患者治疗临床疗效及安全性。结果观察组治疗总有效率为92.68%,明显高于对照组治疗总有效率76.92%,差异有统计学意义(P <0.05)。两组患者治疗前抑郁、焦虑例数比较,差异无统计学意义(P> 0.05)。治疗后,观察组抑郁、焦虑例数明显少于对照组,差异有统计学意义(P <0.05)。治疗后,观察组发作频率、持续时间及VAS评分明显低于对照组,差异有统计学意义(P <0.05)。对照组治疗不良反应发生率明显高于对照组,差异有统计学意义(P <0.05)。结论凉血通瘀方治疗慢性每日头痛有较好的临床疗效,能有效降低头痛发作频率与持续时间,改善患者焦虑与抑郁情况,不良反应发生率较低,值得临床推广运用。
Objective To compare the efficacy and safety of blood-cooling and stasis-removing prescription and pregabalin in treatment of chronic daily headache. Methods 80 patients with chronic daily headache who were admitted to our hospital from September 2015 to September 2017 were selected.According to the random number table method,they weredivided into the control group (n=39) and the observation group (n=41).Patients in the control group were treated with oral pregabalin tabletswhile patients in the observation group were treated withblood-cooling and stasis-removing prescription.The treatment period was 60days.The clinical curative effects and safety of patients in the two groups were compared. Results The total effective rate of observation group was 92.68%,significantly higher than 76.92% of control group(P < 0.05).There was no significant difference in the number of patients with depression and anxiety between the two groups before treatment,P > 0.05.After treatment,patients withdepression and anxiety in the observation group was significantly fewer than those in the control group(P < 0.05). After treatment,the frequency,duration and VAS score of the observation group were significantly lower than those of the control group,P < 0.05.The incidence of adverse reactions in the control group was significantly higher than that in the control group,P < 0.05. Conclusion Blood-cooling and stasis-removing prescriptionin treatment of chronic daily headachehas a better clinical curative effect.It can effectively reduce the frequency and duration of headache attacks,improve anxiety and depression of patients andlower the incidence of adverse reactions,which is worthy of clinical promotion and application.
作者
钟岩
ZHONG Yan(Department of Encephalopathy,Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine,Shenzhen518034,China)
出处
《中国医药科学》
2019年第9期244-246,254,共4页
China Medicine And Pharmacy
关键词
凉血通瘀方
普瑞巴林
慢性每日头痛
安全性
Blood-cooling and stasis-removing prescription
Pregabalin
Chronic daily headache
Safety
