摘要
主动脉壁的稳态失衡及高血压是主动脉瘤和主动脉夹层等主动脉疾病发生的主要原因。转化生长因子β1受体(TGFβ1)通路在血管发育、血管壁稳态维持、高血压发生中均有重要作用。其中I型受体活化生长因子1(ALK1)及其辅助受体内皮糖蛋白(Endoglin)突变是血管动静脉畸形的主要遗传易感原因。因此,本文就TGFβ1及其下游ALK1和Endoglin在主动脉疾病中的研究进展及其可能机制进行综述。
Aortic wall homeostasis and hypertension are the main causes of aortic diseases such as aortic aneurysm and aortic dissection.The transforming growth factor β1 receptor (TGFβ1) pathway plays an important role in vascular development,vascular wall homeostasis and maintenance of hypertension.Mutations of type I receptor-like kinase 1(ALK1) and its co-receptor Endoglin are the main genetic susceptibility reasons for arteriovenous malformations.Therefore,this paper reviews the research progress and possible mechanisms of TGFβ1 and its downstream ALK1 and Endoglin in aortic diseases.
作者
洪俊谋
王志维
Hong Junmou;Wang Zhiwei(Department of Thoracic and Cardiovascular Surgery,Wuhan University Renmin Hospital,Wuhan 430060,China)
出处
《中国临床保健杂志》
CAS
2019年第3期426-429,共4页
Chinese Journal of Clinical Healthcare
基金
国家自然科学基金(81570428
81600367)
关键词
主动脉疾病
受体
转化生长因子β
疾病遗传易感性
血管发育不良
血管畸形
综述
Aortic diseases
Receptors,transforming growth factor beta
Genetic predisposition to disease
Angiodysplasia
Vascular malformations
Review
