摘要
细菌群体感应(quorum sensing,QS)是细菌细胞之间通过感受自诱导物来调控细菌群体行为的现象。细菌生物膜(bacterial biofilm,BBF)是细菌在生长过程中为适应生存环境而吸附于惰性或活性材料表面形成的一种与浮游细胞相应的生物被膜,其结构包括细菌和自身分泌的细胞外基质(extracelluar polymeric substance,EPS)。生物膜可以保护细菌免于外界恶劣环境的影响,增加其抗药性,为细菌生长提供天然的有利屏障。细菌群体感应是细菌调控生物膜形成的重要机制之一,本文中,笔者综述了细菌群体感应在生物膜生成过程中的调控作用,分析了细菌生物膜抑制与降解策略,旨在为医药与食品工业中降低细菌耐药性和细菌抗性提供理论依据。
Bacterial quorum sensing (QS) is a communication system among bacterial cells,which senses the autoinducers and regulates their behaviors to adapt to changes in the environment.Bacterial biofilm (BBF) is a kind of growth mode corresponding to planktonic cells formed by the adsorption of bacteria on the surface of inert or active materials in order to adapt to the living environment.Its structure includes bacteria and extracellular cells secreted by themselves.Biofilms can protect bacteria from external harsh environments and increase their drug resistance,which provide a natural beneficial barrier for bacterial growth.Quorum sensing system is one of the important mechanisms for regulating biofilms formation;we review the regulatory role of QS system in biofilm formation and the strategies based on quorum sensing system for inhibition biofilm formation.The paper could provide theoretical basis for pharmaceutical and food industry to control drug resistance of bacteria.
作者
董汝月
于晓倩
曾名湧
刘尊英
DONG Ruyue;YU Xiaoqian;ZENG Mingyong;LIU Zunying(College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China)
出处
《生物加工过程》
CAS
2019年第3期271-277,共7页
Chinese Journal of Bioprocess Engineering
基金
国家自然科学基金(31671919)
关键词
群体感应
生物膜
群体感应抑制剂
群体感应淬灭
细菌耐药性
quorum sensing
biofilm
quorum sensing inhibitor
quorum quenching
drug resistance of bacteria
