摘要
收集张玉珍教授治疗卵巢早衰的门诊处方,采用"中医传承辅助平台"分析张玉珍教授治疗卵巢早衰的用药规律。结果共筛选出张玉珍教授治疗卵巢早衰的处方151首,涉及中药61味,使用频次在30次以上的中药有菟丝子、当归、女贞子等16味,可归为温补肾阳、补血养阴、补肾益阴、活血行气及健脾益气5类药。151首处方中各药物的性味归经分析结果显示,所用药物药性以温性药为主,其次为寒性药、平性药和凉性药;药味以甘味药为主,其次为辛味药、苦味药、酸味药、咸味药,未涉及涩味药;归经以归肝、肾、脾经为主。药物组合规律分析及网络展示结果显示,张玉珍教授治疗卵巢早衰最为核心的药物是菟丝子、女贞子、丹参、党参、熟地黄、巴戟天、当归、白芍、玉竹,这9味药为张玉珍教授创制的滋癸益经汤的主要组成部分。聚类分析后得到7首候选新处方,这7首新处方以补肾益精、活血化瘀、补肾疏肝、养心安神等药物为主。分析结果提示张玉珍教授在治疗卵巢早衰时,多从肝、肾、脾三经论治,在补益肝肾的同时注重疏肝养肝,养心安神兼活血化瘀通经,疏补结合,并重视患者的心理状况及睡眠情况的调整。
The prescriptions prescribed by professor ZHANG Yu-Zhen for the treatment of premature ovarian failure(POF)in the clinic were collected for the investigation of medication rules for POF by using Traditional Chinese Medicine Inheritance Support Platform(TCMISP). A total of 151 prescriptions involving 62 herbs were enrolled into the analysis. There were 16 herbs(Semen Cuscutae,Radix Angelicae Sinensis,Fructus Ligustri Lucidi, etc.)with the medication frequency above 30, which can be classified into categories of warming-tonifying kidney yang, nourishing blood and yin, tonifying kidney and nourishing yin, activating blood and regulating Qi,and replenishing spleen and strengthening Qi. The properties of the herbs in the 151 prescriptions were dominated by warm herbs,and then came the cold herbs,neutral herbs and cool herbs;the flavors of the herbs were dominated by sweet herbs, and then came the pungent herbs, bitter herbs, sour herbs and salty herbs, and astringent herbs were not used;the herbs were mainly attributed to liver, kidney and spleen meridians. The results of herbal association rule analysis showed that the core herbs of professor ZHANG Yu-Zhen in treating POF were Semen Cuscutae,Fructus Ligustri Lucidi,Radix Salviae Miltiorrhizae,Radix Codonopsis,Radix Rehmanniae Preparata, Radix Morindae Officinalis, Radix Angelicae Sinensis, Radix Paeoniae Alba,and Rhizoma Polygonati Odorati, which were the main composition of Zigui Yijing Decoction prescribed by professor ZHANG Yu-Zhen. The 7 new candidate recipes obtained by cluster analysis were mainly composed of the herbs with the actions of tonifying kidney and nourishing essence,activating blood to resolve stasis,tonifying kidney and soothing liver,and nourishing heart to tranquilize mind. The results indicated that professor ZHANG Yu-Zhen usually adopts the therapies of tonifying liver and kidney,soothing and nourishing liver,nourishing heart to tranquilize mind together with activating blood to resolve stasis and dredging meridians based on regulating the liver,kidney and spleen meridians,which embodies the thoughts of soothing therapy combined with tonifying therapy. Meanwhile,professor ZHANG Yu-Zhen also stresses on the regulation of psychology and sleep of the POF patients.
作者
郭哲璇
廖慧慧
吴咏梅
冯丽
李禺
GUO Zhe-Xuan;LIAO Hui-Hui;WU Yong-Mei;FENG Li;LI Yu(The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2019年第6期905-910,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家中医药管理局张玉珍全国名老中医药专家传承工作室建设项目(国中药人教函[2018]134号)
关键词
卵巢早衰
补益肝肾
疏肝养肝
养心安神
活血化瘀通经
滋癸益经汤
中医传承辅助平台
张玉珍
premature ovarian failure
tonifying liver and kidney
soothing and nourishing liver
nourishing heart to tranquilize mind
activating blood to resolve stasis and dredging meridians
Zigui Yijing Decoction
Traditional Chinese Medicine Inheritance Support Platform
ZHANG Yu-Zhen
