摘要
目的:探讨有氧运动是否通过抑制血管紧张素Ⅱ(angiotensin Ⅱ,Ang Ⅱ)途径改善原发性高血压患者骨骼肌功能性抗交感。方法:36名未经治疗的男性I级原发性高血压患者(收缩压SBP/舒张压DBP:140～159/90～99 mmHg)随机分为运动组(E,n=20)和服药组(D,n=16),E组进行有氧运动,D组服用降压药美托洛尔(β_1-肾上腺素受体阻断剂),干预时间为12周。分别于实验前后:1)测定血压水平的变化;2)利用冷加压实验(CPT)激活交感神经,测定安静时以及握力运动时的前臂血液动力学,交感缩血管反应采用CPT诱导前臂血管电导(FVC)的变化率(%FVC)表示,功能性抗交感(即骨骼肌收缩抑制交感缩血管反应的能力)用肌肉收缩时CPT诱导FVC的变化率与安静时的差值(△%FVC)表示;3)静脉滴注Ang Ⅱ以诱导氧化应激和缩血管反应,测定前臂血管阻力(FVR)和血清8-异前列腺素F_2α(8-iso-PGF_2α)含量。结果:1)血压水平:实验后,E组和D组安静以及握力运动时的血压水平(SBP、DBP和MAP)均显著性下降(P<0.05),但下降幅度组间比较并无显著性差异(P>0.05)。2)交感缩血管反应(%FVC)和功能性抗交感(△%FVC):实验后,E组安静时%FVC升高(P<0.05)、握力运动时%FVC降低(P<0.05),△%FVC增加(P<0.05),D组均无显著性变化(P>0.05)。3)Ang Ⅱ滴注实验:实验前E组和D组FVR和血清8-iso-PGF_2α含量在滴注Ang Ⅱ时均显著性升高(P<0.05),实验后E组无显著性变化(P>0.05),D组则仍高于滴注前水平(P<0.05)。结论:长期有氧运动通过抑制Ang Ⅱ途径改善I级原发性高血压患者骨骼肌功能性抗交感,然而这一效应与血压下降并无关联。
Objective: To investigate whether aerobic exercise improves skeletal muscle functional sympatholysis via inhibition of angiotensin Ⅱ(Ang Ⅱ) pathway in essential hypertension patients. Methods: 36 untreated male stage 1 essential hypertension patients(systolic blood pressure(SBP)/diastolic blood pressure(DBP): 140~159/90~99 mmHg) randomly divided into exercise(E) group ( n = 20) and drug administration( D) group( n = 16) performed aerobic exercise or antihypertensive agent Metoprolol(β1-adrenergic receptor blocker) for 12 weeks. Before and after experiment:1) change of blood pressure level was determined;2) forearm hemodynamic responses to reflex increases in sympathetic nerve activity evoked by cold pressor test( CPT) at rest and during handgrip exercise were determined. Sympathetic vasoconstriction was represented as forearm vascular conductance( FVC) change rate(△% FVC) and functional sympatholysis( the capacity of skeletal muscle contraction to suppress sympathetic vasoconstrictor response) as the difference of CPT induced FVC change rate between during muscular contraction and at rest(△% FVC);3) intravenous infusion of Ang Ⅱ was conducted to induce oxidative stress and vasoconstriction and forearm vascular resistance( FVR) as well as serum 8-iso-prostaglandin( 8-iso-PGF2α) content were measured. Results:1) Blood pressure level: after test,blood pressure( SBP,DBP and MAP) at rest and and during handgrip exercise reduced in both E and D groups( P < 0. 05),but there was no significant difference of reduction extent between groups( P > 0. 05). 2) sympathetic vasoconstriction response(%FVC) and functional sympatholysis(△% FVC): after experiment,% FVC at rest and △% FVC increased while % FVC during handgrip exercise decreased in E group( P < 0. 05),but the effects above were not observed in D group( P > 0. 05). 3) Ang Ⅱ infusion test: after infusion,FVR and serum 8-iso-PGF2α increased of both E and D groups before experiment( P < 0. 05);after experiment,there was no sighnificant change in E group( P > 0. 05) while still higher than pre-infusion in D group( P < 0. 05). Conclusion: Long-term aerobic exercise improved skeletal muscle functional sympatholysis via inhibition of Ang Ⅱ pathway but not reduction of blood pressure in stage1 essential hypertension patients.
作者
程蕾
于乐
孙一
裴晶晶
CHENG Lei;YU Le;SUN Yi;PEI Jing-jing(Sichuan International Studies University,Chongqing 400031,China;School of P.E.,Jilin University,Changchun 130012,Jilin,China)
出处
《山东体育学院学报》
北大核心
2019年第2期90-98,共9页
Journal of Shandong Sport University
基金
吉林大学基本科研项目"关于高校运动队体能训练的科学化研究"(XN2014TY01)
关键词
有氧运动
原发性高血压
交感缩血管反应
功能性抗交感
血管紧张素Ⅱ
氧化应激
aerobic exercise
essential hypertension
sympathetic vasoconstriction response
functional sympatholysis
angiotensin Ⅱ
oxidative stress
