摘要
介绍了一种全新的有机中间体3,5-二氯苯甲酰氯的合成路线,以对氨基苯甲酸为原料以乙酸为溶剂并在三氯化铁的催化下与氯气接触进行氯化反应,再通过低温重氮化反应脱去四号位的氨基,最后与氯化亚砜反应得到目的产物3,5-二氯苯甲酰氯,经过对反应条件参数的优化,最终反应总收率能达到75%以上。本方法具有反应原料易得,价格合适,三废少且反应条件温和等优点,适用于工业化生产。
This paper introduces a new synthetic route of 3,5-dichlorobenzoyl chloride.The p-aminobenzoic acid is used as a raw material,and the acetic acid is used as a solvent to carry out chlorination under the action of ferric chloride.The amino group at the 4 th position is removed by low temperature diazotization.Finally,it is reacted with thionyl chloride to obtain the target product 3,5-dichlorobenzoyl chloride.After optimizing the reaction parameters,the total yield of the reaction is more than 75%.The advantages of this methods include the easy availability and moderate price of starting material,fewer three wastes,and mild reaction conditions.Therefore,this method is suitable for industrial production.
作者
曾礼
张耀宗
董德源
董梦依
余勃
陆豫
ZENG Li;ZHANG Yaozhong;DONG Deyuan;DONG Mengyi;YU Bo;LU Yu(School of Chemistry,Nanchang University, Nanchang 330031,China;School of Environment and Chemical Engineering,Nanchang University, Nanchang 330031,China;Sino-German Joint Research Institute,Nanchang University,Nanchang 330047,China)
出处
《南昌大学学报（理科版）》
CAS
北大核心
2019年第1期65-69,共5页
Journal of Nanchang University(Natural Science)
基金
国家自然科学基金资助项目(31560484)
江西省科技厅重点研发项目(20171BBF60005)
