摘要
系统性红斑狼疮(SLE)作为自身免疫性疾病,以产生多种自身抗体从而导致不同靶器官损害为显著特点,其发病机制及病因尚未明确。树突状细胞(DCs)具有诱导免疫应答和免疫耐受双向调控的重要作用,DCs免疫耐受失衡可导致T、B细胞异常活化,进而出现多系统、多器官损伤。中性粒细胞(PMN)在免疫应答和免疫调控中扮演着重要的角色。本文通过探讨树突状细胞及中性粒细胞在SLE发病中作用的概述,旨在为SLE发病机制的探究奠定基础。
Systemic lupus erythematosus(SLE),as an autoimmune disease,produces a variety of autoantibodies that cause significant damage to different target organs.The pathogenesis and etiology are not well defined.Dendritic cells(DCs)play an important role in the induction of immune response and immune tolerance.The imbalance of DCs immune tolerance can lead to the abnormal activation of T and B cells,resulting in multiple system and multiple organ damage.Neutrophils(PMN)play an important role in immune response and immune regulation.This article aims to lay the foundation for the study of the pathogenesis of SLE by an overview of the role of PMN.mediated differentiation and regulation of DC in the pathogenesis of SLE.
作者
卿平英
刘毅
QING Pingying;LIU Yi(Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu,Sichuan,China,610041)
出处
《分子诊断与治疗杂志》
2019年第3期245-248,共4页
Journal of Molecular Diagnostics and Therapy
基金
中华医学会风湿病学分会燎原计划(IYJH-337)
