摘要
恶性肿瘤骨转移常引起疼痛、功能障碍、病理性骨折、脊髓压迫等症状,严重影响患者的生存质量。双膦酸盐为破骨细胞强效抑制剂,可有效预防和减少相关症状,是治疗恶性肿瘤骨转移的主要措施之一。因卡膦酸二钠是第3代双膦酸盐制剂,其对于恶性肿瘤转移导致的骨质疏松、疼痛、骨折等相关症状的治疗优于第1、2代双膦酸盐药物;并可调控肿瘤细胞的增殖与凋亡。同时,研究资料表明因卡膦酸二钠药物相关发热、肾功能损害、颌骨坏死等不良反应的发生率低。对于因卡膦酸二钠的剂量、用法、疗程及停药时机需要深入研究,不良反应和有效性需要长期追踪。
Bone metastasis caused by cancer often cause significant symptoms, such as pain, impaired function, pathological fracture, spinal cord compression, etc. Bisphosphonate is a potent osteoclast inhibitor, which can effectively prevent and reduce related symptoms, and is standard therapeutic drug for cancer patients with bone metastasis. As the third-generation bisphosphonates,bicarbonate disodium is superior to the first-generation and second-generation bisphosphonates in the treatment of osteoporosis, pain,fracture and other related symptoms caused by malignant tumor metastasis, and can regulate the proliferation and apoptosis of tumor cells. Some study show that the incidence of adverse reactions such as pyretic renal function damage and osteonecrosis of jaw is low.The dosage, treatment course and timing of withdrawal of bicarbonate disodium require in-depth study, and adverse reactions and effectiveness require long-term follow-up.
作者
冯晨
李中梨
张文学
FENG Chen;LI Zhong-li;ZHANG Wen-xue(Department of Radiotherapy, Shanxi Provincial Corp's Hospital, Xi'an 710054,China;Department of Radiotherapy, the First Affiliated Hospital of Lishui College, Zhejiang, Lishui 323000, China;Departmentof Radiotherapy, General Hospital of Tianjin Medical University, Tianjin 300052, China)
出处
《肿瘤综合治疗电子杂志》
2019年第2期46-49,共4页
Journal of Multidisciplinary Cancer Management(Electronic Version)
关键词
双膦酸盐
骨转移
因卡膦酸二钠
疗效
不良反应
Bisphosphonate
Bone metastasis
Bicarbonate disodium
Therapeutic effect
Adverse reactions
