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首发重性抑郁障碍病人血脂谱水平与其自杀行为的相关性研究 被引量:1

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摘要 目的探讨首发重性抑郁障碍(MDD)病人自杀行为与血脂谱水平的相关性。方法收集首发未用药的MDD病人276例作为研究对象,收集其一般人口学资料,并进行汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评分,抽取受试者空腹静脉血测定空腹血糖和血脂谱等指标,采用Logistic回归模型分析首发MDD病人自杀行为与血脂总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平的相关性。结果首发MDD病人的自杀行为与血清TC水平呈正相关关系(P<0.05),与HDL-C水平呈负相关关系(P<0.05),且在对性别和年龄分层后,这种关系依然存在。分别对不同年龄和不同性别首发MDD病人的自杀行为与血脂谱分析发现,男性病人的年龄与自杀行为呈负相关关系(P<0.05),18~44岁年龄段男性和女性病人的血清TG和LDL-C水平与自杀行为呈负相关关系(P<0.05)。结论首发MDD病人自杀行为与血清TC、HDL-C水平有关。男性病人自杀行为与年龄相关。18~44岁年龄段病人的自杀行为危险因素还包括血清TC水平升高,TG和LDL-C水平下降。
出处 《中西医结合心脑血管病杂志》 2019年第9期1414-1417,共4页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
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