摘要
目的观察益生菌联合大黄对胆汁淤积性肝病婴儿肠道菌群及炎性因子的影响。方法选取2017年3月至2018年3月本院收治的96例胆汁淤积性肝病婴儿(< 1周岁)为研究对象,依据入院顺序奇偶数将其随机分为观察组(48例)和对照组(48例),均行常规治疗,在此基础上,对照组患儿加用益生菌治疗,观察组患儿加用益生菌联合大黄治疗,比较两组患儿治疗前后肝功能指标[丙氨酸转氨酶(alanine aminotransferase,ALT)、碱性磷酸酶(alkaline phosphatase,ALP)、总胆汁酸(totalbile acid,TBA)、直接胆红素(direct bilirubin,DBIL)、总胆红素(total bilirubin,TBIL)]、炎性因子[白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、肠道菌群分布及不良反应发生情况。结果治疗后,两组患儿ALT、ALP、TBA、DBIL、TBIL、IL-6、TNF-α水平均显著低于本组治疗前(P均< 0.05),且观察组患儿上述指标水平均显著低于同期对照组(P均< 0.05)。治疗后,两组患儿大肠杆菌数量均显著少于本组治疗前(P均< 0.05),乳酸杆菌和双歧杆菌数量均显著多于本组治疗前(P均< 0.05),B/E值均显著大于本组治疗前(P均< 0.05);且观察组患儿大肠杆菌数量均显著少于同期对照组(P < 0.05),乳酸杆菌和双歧杆菌数量均显著多于同期对照组(P均< 0.05),B/E值显著大于同期对照组(P < 0.05)。两组患儿治疗期间不良反应总发生率比较无明显差异(P = 0.484)。结论益生菌联合大黄可有效改善胆汁淤积性肝病婴儿肠道菌群,减轻患儿炎性反应,促进其肝功能恢复,且安全性良好。
Objective To observe the effect of probiotics combined with rhubarb on intestinal flora and inflammatory factors in infants with cholestasis liver disease. Method From March 2017 to March 2018, 96 infants (less than 1 year old) with cholestasis liver disease who were admitted to the hospital were randomly divided into observation group (n = 48) and control group (n = 48) according to even-odd order of admission, all infants were treated with routine treatment, on this basis, infants in control group were treated with probiotics, while infants in observation group were treated with probiotics combined with rhubarb. The levels of liver function indexes [alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bile acid (TBA), direct bilirubin (DBIL), total bilirubin (TBIL)] and inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α)], the distribution of intestinal flora and the occurrence of adverse reactions were compared between the two groups before and after treatment. Result After treatment, levels of ALT, ALP, TBA, DBIL, TBIL, IL-6 and TNF-α in the two groups were significantly lower than those before treatment (Pall < 0.05), the levels of the above indexes in observation group were significantly lower than those in control group in the same period (Pall < 0.05). After treatment, Escherichia coli in both groups were significantly less than those before treatment (Pall < 0.05), Lactobacillus and Bifidobacteriales were significantly more than those before treatment (Pall < 0.05), and B/E value were significantly higher than those before treatment (Pall < 0.05). Escherichia coli in observation group was significantly less than that in control group in the same period (P < 0.05), while Lactobacillus and Bifidobacteriales were significantly more than those in control group in the same period (Pall < 0.05), B/E value was significantly higher than that of control group in the same period (P < 0.05). There was no significant difference in total incidence of adverse reactions between the two groups during treatment period (P = 0.484). Conclusion Probiotics combined with rhubarb can effectively improve the intestinal flora of infants with cholestatic liver disease, reduce their inflammatory reactions, promote recovery of liver function, and the safety is good.
作者
刘圣烜
李雪松
黄志华
董琛
LIU Sheng-xuan;LI Xue-song;HUANG Zhi-hua;DONG Chen(Department of Pediatrics,Tongji Hospital,Tongji Medical CollegeHuazhong University of Science and Technology,Wuhan 430030,China)
出处
《中国医学前沿杂志（电子版）》
2019年第5期58-61,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
益生菌
大黄
婴儿
胆汁淤积性肝病
肠道菌群
炎性因子
Probiotics
Rhubarb
Infant
Cholestasis liver disease
Intestinal flora
Inflammatory factor
