摘要
目的 探讨消结安胶囊与桂枝茯苓胶囊辅助治疗乳腺增生的疗效观察。方法 选取本院2015年1月至2017年5月收治的140例乳腺增生患者进行研究,按随机数字表法将其分为两组,各70例。对照组患者采用桂枝茯苓胶囊治疗,研究组在此基础上加用消结安胶囊治疗,治疗后比较两组患者治疗效果、乳房肿块改善情况、性激素改善情况及不良反应发生情况。结果 研究组治疗总有效率、复发率分别为95.71%(67/70)、4.29%(3/70),与对照组91.43%(64/70)、7.14%(5/70)比较,差异均无统计学意义(均P>0.05);研究组治愈率61.43%(43/70),高于对照组41.43%(29/70),差异有统计学意义(P<0.05);治疗后,研究组乳房肿块硬度、肿块大小分别为(1.03±0.15)、(1.21±0.17),均低于对照组,差异均有统计学意义(均P<0.05);治疗后,研究组E2水平(1253.27±135.18)pmol/L,低于对照组,LH、P水平(20.34±3.12)U/L、(6.28±0.67)nmol/L,高于对照组,差异均有统计学意义(均P<0.05);研究组不良反应发生率8.57%(6/70),与对照组11.43%(8/70)比较,差异无统计学意义(P>0.05)。结论 消结安胶囊与桂枝茯苓胶囊联合治疗可显著改善乳腺增生患者性激素表达水平及临床症状,疗效及安全性较好。
Objective To investigate the effect of Guizhi Fuling capsules and Xiaojie'an capsules in the treatment of hyperplasia of mammary glands. Methods 140 patients with hyperplasia of mammary glands treated at our hospital from January, 2015 to May, 2017 were chosen as experimental objects, and were divided into a control group and a research group, 70 cases for each group. The control group were treated with Guizhi Fuling capsules, and the research group with Guizhi Fuling capsules and Xiaojie'an capsules. After the treatment, the treatment effect, improvement of breast lump, improvement of sex hormones, and adverse reactions compared between the two groups. Results The total effective rate and recurrence rate were 95.71%(67/70) and 4.29%(3/70) in the research group, and were 91.43%(64/70) and 7.14%(5/70) in the control group, with no statistical differences (both P > 0.05). The cured rate was higher in the research group than in the control group [61.43%(43/70) vs. 41.43%(29/70), P < 0.05]. After the treatment, the hardness and mass size of the breast lumps in the research group were (1.03±0.15) and (1.21±0.17), which were lower than those in the control group, with statistical differences (both P < 0.05). After the treatment, the levels of E2, LH, and P were (1 253.27±135.18) pmol/L,(20.34±3.12) U/L, and (6.28±0.67) nmol/L in the research group, which were better than those in the control group, with statistical differences (all P < 0.05). The incidence of adverse reactions was 8.57%(6/70) in the research group, and was 11.43%(8/70) in the control group (P > 0.05).Conclusion Guizhi Fuling capsules combined with Xiaojie'an capsules for patients with hyperplasia of mammary glands can significantly improve the levels of sex hormones and clinical symptoms, and is effective and safe.
作者
张超
潘延成
Zhang Chao;Pan Yancheng(Department of Pharmacy, Tengzhou Central People’s Hospital, Tengzhou 277500,China)
出处
《国际医药卫生导报》
2019年第10期1618-1621,共4页
International Medicine and Health Guidance News
关键词
乳腺增生
桂枝茯苓胶囊
消结安胶囊
性激素
Hyperplasia of mammary glands
Guizhi Fuling capsules
Xiaojie'an capsules
Sex hormones
