摘要
目的探讨四君子汤联合雷替曲塞和奥沙利铂治疗晚期肝癌的疗效及对免疫功能的影响。方法将104例晚期肝癌患者分为观察组和对照组。对照组采用雷替曲塞和奥沙利铂治疗,观察组在对照组治疗基础上加用四君子汤治疗,21 d为1个化疗周期,治疗2个周期。采用RECIST标准评估2组的疗效,检测2组治疗前后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、NK细胞水平,采用原发性肝癌症状分级量化表评估2组治疗前后中医症状评分,记录2组不良反应发生情况。结果 2组缓解率比较差异无统计学意义(P>0.05);观察组的有效率明显高于对照组(P<0.05);2组治疗后CD3^+、CD4^+、CD4^+/CD8^+、NK细胞均显著升高(P均<0.05),且观察组治疗后CD3^+、CD4^+、CD4^+/CD8^+、NK细胞均明显高于对照组(P均<0.05);2组治疗后胁痛、神疲乏力、腹胀、纳呆食少、胁下痞块、大便溏泄、少气懒言、恶心、呕吐、口粘不欲饮、舌象、脉象评分及中医症状评分均显著降低(P均<0.05),且观察组治疗后上述评分均明显低于对照组(P均<0.05);观察组胃肠道反应、白细胞降低、发热、贫血发生率均明显低于对照组(P均<0.05)。结论四君子汤可明显提高晚期肝癌的疗效,改善免疫功能。
Objective It is to investigate the efficacy of Sijunzi Decoction combined with raltitrexed and oxaliplatin in the treatment of advanced liver cancer and its effect on immune function. Methods 104 patients with advanced liver cancer were divided into observation group and control group. The control group was treated with raltitrexed and oxaliplatin. The observation group was treated with Sijunzi Decoction on the basis of the control group. 21 days as one chemotherapy cycle, they were treated for 2 cycles. The efficacy of the two groups was evaluated by RECIST criteria. The levels of CD3^+, CD4^+, CD4^+/CD8^+ and NK cells were measured, the scores of TCM symptoms before and after treatment were evaluated by the primary liver cancer symptom classification table in the two groups, the occurrence of side effects were recorded. Results There was no significant difference in the remission rate between the two groups ( P >0.05). The effective rate of the observation group was significantly higher than that of the control group ( P <0.05). The levels of CD3^+, CD4^+, CD4^+/CD8^+ and NK cells were significantly increased after treatment in the two groups ( P <0.05), and the levels of CD3^+, CD4^+, CD4^+/CD8^+ and NK cells in the observation group were significantly higher than those in the control group ( P <0.05). The scores of costalgia, fatigue, abdominal distension, anepithymia, loose stool, nausea, vomiting, mouth sticking, tongue image, pulse image were significantly decreased ( P <0.05), and the scores of every symptom in the observation group after treatment were significantly lower than those in the control group ( P <0.05). The incidence of gastrointestinal reactions, leukopenia, fever and anemia were significantly lower in the observation group than that in the control group ( P <0.05). Conclusion Sijunzi Decoction can improve the efficacy on advanced liver cancer and improve immune function.
作者
赵华
ZHAO Hua(Shaanxi Provincial Cancer Hospital, Xi'an 710061, Shaanxi, China)
出处
《现代中西医结合杂志》
CAS
2019年第15期1630-1633,1644,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
四君子汤
雷替曲塞
奥沙利铂
晚期肝癌
免疫功能
Sijunzi Decoction
raltitrexed
oxaliplatin
advanced liver cancer
immune function
