摘要
目的Na^18F是一种主要用于诊断成骨反应活性程度增加的骨疾病的正电子计算机断层显像药物,肿瘤骨转移的诊断是其重要的适应症之一。本研究旨在对Na18FPET/CT用于肿瘤骨转移诊断的诊断效果进行系统评价。方法对2000年1月1日至2018年12月31日公开发表的Na^18F PET/CT诊断骨转移的文献用计算机检索中英文数据库,根据纳入与排除标准筛选出符合要求的文献,进行数据提取和质量评价,采用Stata 12.00软件进行Meta分析。结果共35篇文献纳入本研究,中文文献9篇,英文文献26篇。Meta分析结果显示:①Na^18F PET/CT诊断骨转移的灵敏度、特异性、阳性似然比、阴性似然比、曲线下面积,以患者为计算基础时分别为0.97、0.93、14.5、0.03和0.99;以病灶为计算基础时分别为0.96、0.88、8.3、0.05和0.98;②对不同原发灶(肺癌、乳腺癌及前列腺癌)的ROC曲线比较可知:三种不同的原发灶之间均无显著性差异;③所有纳入本研究的文献未见有使用Na18F后出现不良反应的报道。结论无论以患者还是以病灶为基础,Na^18F PET/CT诊断骨转移的效能均很好,Na^18F PET/CT对肺癌、乳腺癌和前列腺癌骨转移的诊断效能无明显差异,未见使用Na18F后出现不良反应的报道。
Objective Sodium(18F)fluoride injection is a radioactive diagnostic agent for positron emission tomography(PET)indicated for imaging of bone to define areas of altered osteogenic activity.The diagnosis of bone metastasis is one of its important indications.The objective of this study was to systematically evaluate the diagnosis effect of Na^18F PET/CT for the diagnosis of bone metastases.Methods The literatures about Na^18F PET/CT for the diagnosis of bone metastases,published between January 1,2000 to December 31,2018,were computationally searched in both the English database and the Chinese database.The qualified literatures were selected according to the inclusive and exclusive standards.Data extraction and quality evaluation were the performed.A meta-analysis was performed using Stata 12.00 software.Based on the searching,a total of 35 literatures were selected in this study,including 9 Chinese literatures and 26 English literatures.Results The results of the meta-analysis showed that:①The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and the area under the curve of Na^18F PET/CT in the diagnosis of bone metastasis were 0.9,0.93,14.5 0.03 and 0.99 based on the patients,respectively.Based on the lesions,these results were 0.96,0.88,8.3,0.05 and 0.98 respectively;②The intercomparison of ROC curves of different primary lesions(lung cancer,breast cancer and prostate cancer)showed that there were no significant differences among these three types of primary lesions;③There were no reports of adverse reactions after the use of Na^18F in all the literatures in this study.Conclusion Na^18F PET/CT has a good performance in the diagnosis of bone metastasis,based on both the patients or the lesions.There are no significant differences in the diagnosis of bone metastasis of lung cancer,breast cancer and prostate cancer,and no adverse reactions have been reported after the use of Na18^F.
作者
郭飞虎
成伟华
费月英
徐晓敏
吴建爽
阚英
杨吉刚
GUO Fei-hu;CHENG Wei-hua;FEI Yue-ying;XU Xiao-min;WU Jian-shuang;KAn Ying;YANG Ji-gang(High Tech of Atom Co.Ltd.,Beifang,Beijing 102413,China;Department of Nuclear Medicine,Beijing Friendship Hospital of Capital,Medical University,Beijing 100050,China)
出处
《标记免疫分析与临床》
CAS
2019年第5期786-794,836,共10页
Labeled Immunoassays and Clinical Medicine
基金
国家自然科学基金(编号:81771860)
