摘要
目的探讨原发肺黏膜相关淋巴组织(mucosa-associated lymphoid tissue,MALT)淋巴瘤的临床症状、影像学表现、治疗方法及其预后。方法回顾性分析中国医学科学院北京协和医学院肿瘤医院2006年1月至2015年8月收治的16例肺MALT淋巴瘤患者的临床、影像学和随访资料。结果 16例肺MALT淋巴瘤患者中,男8例,女8例,男女比例1:1,发病年龄31～80岁,中位年龄59岁。患者的主要临床症状包括咳嗽咳痰7例、胸闷3例、胸痛2例、咯血2例、发热3例、盗汗1例,有8例患者无明显症状。胸部CT影像4例表现为伴支气管充气征的肺实变影,5例表现为肺部结节,4例表现为肺部肿物,3例表现为肺磨玻璃影,2例表现为双肺多发病变,另有6例伴纵隔淋巴结肿大,3例伴胸腔积液。14例患者行手术切除,其中2例术前行新辅助化疗,4例术后行辅助化疗,1例术后行辅助化疗,7例患者行单纯手术治疗。1例患者行化疗序贯放疗。1例患者单纯行化疗。16例均获随访,随访时间1～10年,1例死亡,15例存活。结论肺MALT淋巴瘤的临床症状及影像学表现缺乏特异性,确诊需依靠病理学及免疫组织化学检查。单纯手术切除可使局限性肺MALT淋巴瘤患者获得较好的治疗效果。
Objective To discuss the clinical and imaging features as well as the treatment and prognosis of primary pulmonary mucosaassociated lymphoid tissue (MALT) lymphoma. Method A retrospective analysis was performed on the clinical data of 16 patients with primary pulmonary MALT lymphoma from Janurary 2006 to August 2015. Result Of the 16 patients with pulmonary MALT lymphoma, 8 were male and 8 were female (1:1 ratio). The age of onset varies from 31 years to 80 years, and the median age is 59 years. The main clinical symptoms of the 16 cases included cough and expectoration (n=7), dyspnea (n=3), chest pain (n=2), hemoptysis (n=2), fever (n=3) and night sweat (n=1). No symptoms were found in 8 patients. The chest CT of the patients showed pulmonary consolidation with air bronchogram in 4 cases, nodule shadow in 5 cases, mass shadow in 4 cases, and ground-glass opacity in 3 cases. In addition, 2 cases showed bilateral pulmonary multiple changes, 6 showed mediastinal lymph node enlargement, and 3 showed pleural effusion. Operation was performed on 14 patients, 2 of which were given preoperative adjuvant chemotherapy, 4 of which were given postoperative adjuvant chemotherapy and 1 of which were given postoperative adjuvant radiotherapy. 1 patient underwent chemotherapy and radiotherapy. 1 patient underwent chemotherapy only. The follow-up period ranged from 1 year to 10 years. 1 patients died and 15 patients were still alive. Conclusion The clinical feature of pulmonary MALT lymphoma is not typical. Thus, imaging techniques cannot detect specifi c changes. To patients with limited lesions, the prognosis of Surgical resection is generally good.
作者
杨昆
薛奇
YANG Kun;XUE Qi(Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China)
出处
《中国医刊》
CAS
2019年第6期655-657,共3页
Chinese Journal of Medicine
关键词
黏膜相关淋巴组织淋巴瘤
临床病理
肺部肿瘤
Mucosa-associated lymphoid tissue lymphoma
Clinicopathologic features
Pulmonary neoplasm
