摘要
目的探讨临床药师干预对反复发作的失眠症患者用药依从性及治疗效果的影响。方法选择2014年7月至2017年7月于浙江省宁波市康宁医院确诊的80例反复发作的失眠症患者作为研究对象,随机分为干预组和对照组,每组40例。干预组患者使用镇静催眠药物治疗的同时实施临床药师干预,包括给予患者药物知识讲解、接受患者及其家属的用药咨询等;对照组患者使用镇静催眠药物治疗时未实施临床药师干预。两组患者均连续服药4周,并于治疗开始后监测及评估治疗反应。结果两组均随访4周,其中干预组脱落3例,有效入组37例,对照组脱落8例,有效入组32例。干预前两组患者的性别、年龄、病程、受教育年限等差异无显著性(P>0.05)。80例反复发作的失眠症患者对镇静催眠药物的用药依从性差的主要表现形式包括忘记吃药(10.34%)、随意停药换药(37.93%)、随意加减剂量(24.14%)、随意改变服药时间或服药次数(27.58%)。药师干预前干预组和对照组患者的用药依从性分别为19.35%和15.63%,差异无显著性(P>0.05);药师干预后两组患者的用药依从性均有所改善,分别为75.68%和28.13%,且干预组明显高于对照组,差异有显著性(P<0.001)。两组经连续4周药物治疗后临床症状均有不同程度的改善,且干预组的治疗有效率(86.49%)明显高于对照组(59.38%),差异有显著性(χ~2=10.9747,P=0.0119)。结论临床药师干预可有效提高反复发作的失眠症患者的服药依从性和临床治疗效果。
Objective Explore the medication compliance and therapeutic effect of patients with recurrent episodes of insomnia by intervention of clinical pharmacist Method From July 2014 to July 2017, eighty patients with recurrent insomnia diagnosed in Ningbo Kangning Hospital in Zhejiang Province were selected as research objects, and divided into Intervention group and control group randomly, each group had 40 cases. The patients in the intervention group were treated with sedative hypnotic drugs while the pharmacist intervened, including giving the explanation of drug knowledge and receiving medication consultation from patients and their families. The patients in the control group were only treated with sedative hypnotic drugs. The two groups were treated for 4 weeks, and all patients were monitored and evaluated after treatment. Result Clinical follow-up study for 4weeks,total effective cases in intervention group were 37 and fell off 3cases. Control group were 32 and fell off 8 cases. There was no signifi cant differences between two groups before intervention in gender, age, course of disease and educational background (P>0.05). Recurrent insomnia patients with poor to medication adherence of sedative hypnotic drugs included forgetting to take medicine (10.34%), the major forms of voluntary withdrawal treatment (37.93%), adding and subtracting dosage (24.14%) and changing time or frequency willfully (27.58%). Before intervention, the medication compliance of the two groups was 19.35% and 15.63% respectively, and the two groups had no signifi cant difference (P>0.05). After intervention, the two groups of patients was improved their medication compliance, the medication compliance of the two groups was 75.68% and 28.13% respectively, and the intervention group was signifi cantly higher than the control group, the difference was signifi cant (P<0.001). After 4 weeks of continuous drug treatment ,the two groups of patients with clinical symptoms were improved to varying degrees. The effective rate of 86.49% in the intervention group was better than 53.38% in the control group, with statistical difference (χ2 =10.9747, P=0.0119). Conclusion The intervention of clinical pharmacists can effectively improve the compliance of patients with insomnia and the effect of clinical treatment.
作者
黄敏芳
唐亚芳
张巧真
于静
周东升
HUANG Min-fang;TANG Ya-fang;ZHANG Qiao-zhen;YU Jing;ZHOU Dong-sheng(Department of Pharmacy, Ningbo Kangning Hospital, Zhejiang Ningbo 315201, China;Department of Science and Education, Ningbo Kangning Hospital, Zhejiang Ningbo 315201,China)
出处
《中国医刊》
CAS
2019年第6期667-670,共4页
Chinese Journal of Medicine
基金
浙江省药学会医院药学专项科研项目(2013ZYY10)
关键词
临床药师
干预
用药依从性
影响因素
失眠症
治疗效果
Clinical pharmacist
Intervention
Medication compliance
Infl uencing factors
Insomnia
Treatment effect
