摘要
目的分析血清鳞状细胞癌相关抗原(SCC-Ag)与细胞角蛋白19片段(CYFRA21-1)在宫颈癌患者体内的表达水平及其联合检测的临床意义。方法选择2014年3月至2017年2月该院收治的宫颈癌患者34例作为A组,宫颈癌上皮内瘤样病变患者31例作为B组,同期健康体检的健康女性30例作为C组。对各组研究对象不同组织类型、不同临床分期患者血清SCC-Ag与CYFRA21-1水平进行测定。结果 3组研究对象SCC-Ag、CYFRA21-1水平比较,差异均有统计学差异(P<0.05)。A组患者血清SCC-Ag、CYFRA21-1水平均明显高于B组、C组,B组患者血清SCC-A、CYFRA21-1g水平均明显高于C组,差异均有统计学意义(P<0.05);血清SCC-Ag、CYFRA21-1水平从低至高依次为宫颈癌Ⅰ期、Ⅱ期、Ⅲ～Ⅳ期患者,差异均有统计学意义(P<0.05);鳞癌患者血清SCC-Ag阳性率均明显高于腺癌、腺鳞癌,差异均有统计学意义(P<0.05);腺鳞癌患者血清CYFRA21-1阳性率均明显高于鳞癌、腺癌,差异均有统计学意义(P<0.05)。血清SCC-Ag联合CYFRA21-1诊断宫颈癌的灵敏度、准确度和特异性分别为0.971、0.952和0.828。结论血清SCC-Ag与CYFRA21-1在宫颈癌患者体内的表达水平均显著升高,2项指标联合检测可作为临床诊断宫颈癌及评估患者预后的重要指标。
Objective To analyze the expression level of serum SCC-Ag and CYFRA21-1 in patients with cervical cancer and its clinical significance.Methods Totally 34 patients with cervical cancer,who were treated in the hospital from March 2014 to February 2017,were selected as group A,simultaneously,31 patients with intraepithelial neoplasia of cervical cancer were selected as group B and 30 healthy women who underwent physical examination in the hospital were selected as group C.Serum SCC-Ag and CYFRA21-1 levels in all the groups were measured among patients with different tissue types and different clinical stages.Results The results of ANOVA showed that there were statistically significant difference on the levels of serum SCC-Ag and CYFRA21-1 among the three groups (P<0.05).The levels of serum SCC-Ag and CYFRA21-1 in the group A were higher than those in the group B and group C,while the level of serum SCC-Ag in the group B was higher than that in the group C,the difference showed statistical significance (P<0.05).The serum levels of SCC-Ag,CYFRA21-1 from low to high were patients with cervical cancer in stage Ⅰ,stage Ⅱ,and stage Ⅲ-Ⅳ successively,there was statistically significant difference (P<0.05).The positive rate of serum SCC-Ag in patients with squamous cell carcinoma was significantly higher than that in patients with adenocarcinoma and adenosquamous carcinoma,and the positive rate of serum CYFRA21-1 in patients with adenosquamous carcinoma was significantly higher than that in patients with squamous cell carcinoma and adenocarcinoma,the difference had statistical significance (P<0.05).The sensitivity,accuracy and specificity of serum SCC-Ag combined with CYFRA21-1 in the diagnosis of cervical cancer were 0.971,0.952 and 0.828,respectively.Conclusion The expression level of serum SCC-Ag and CYFRA21-1 significantly increased in patients with cervical cancer,the combined detection of serum SCC-Ag and CYFRA21-1 can be used as an important index for clinical diagnosis and prognosis evaluation of cervical cancer patients.
作者
唐珍
TANG Zhen(Department of Clinical Laboratory,Suzhou Municipal Hospital,Suzhou,Jiangsu 215000,China)
出处
《国际检验医学杂志》
CAS
2019年第10期1213-1215,1222,共4页
International Journal of Laboratory Medicine
关键词
血清
宫颈肿瘤/诊断
预后
鳞状细胞癌相关抗原
细胞角蛋白19片段
serum
uterine cervical neoplasms/diagnosis
prognosis
squamous cell carcinoma antigen
cytokeratin fragment antiogen 21-1
