摘要
目的探讨循环肿瘤细胞在肺癌中的应用及其临床意义。方法对60例不同类型和分期的肺癌患者、10例良性肺疾病患者、10例健康志愿者外周血中循环肿瘤细胞阳性率进行比较,分析循环肿瘤细胞与肺癌的相关性。结果肺癌患者组的循环肿瘤细胞阳性率达80%,良性肺疾病患者组和健康组的阳性率为0,差异具有统计学意义(P <0. 05)。循环肿瘤细胞阳性表达与肺癌类型、患者性别无明显关系(P> 0. 05),Ⅰ期肺癌患者中CTC阳性率(40. 00%)显著低于Ⅱ、Ⅲ、Ⅳ期的患者CTC阳性率(85. 71%、88. 24%、100. 00%),差异具有统计学意义(P <0. 05)。结论检查外周血中循环肿瘤细胞,有望成为肺癌的诊断及预后评估的辅助手段。
Objective To explore the application of circulating tumor cell( CTC) in lung cancer and its clinical significance. Methods The positive rates of CTC in 60 patients with different types and stages of lung cancer,10 patients with benign lung disease and 10 healthy volunteers were compared,and the correlation between CTC and lung cancer was analyzed. Results The positive rate of CTC was 80% in patients with lung cancer and zero in benign lung disease and healthy group respectively.The difference was statistically significant( P < 0. 05). The positive expression of CTC had no significant relationship with the type of lung cancer and the gender of patients( P > 0. 05). The positive rate of CTC in patients with stage Ⅰ lung cancer( 40%)was significantly lower than that in patients with stage Ⅱ,Ⅲ and Ⅳ( 85. 71%,88. 24%,100% respectively). The difference was statistically significant( P < 0. 05). Conclusion Examination of circulating tumor cells in peripheral blood is expected to be an adjunct to the diagnosis and prognosis of lung cancer.
作者
骆许静
马耀先
孙桢
方晓瑞
申晓燕
LUO Xujing;MA Yaoxian;SUN Zhen(Xuchang Central Hospital,Xuchang,461000)
出处
《实用癌症杂志》
2019年第5期753-755,共3页
The Practical Journal of Cancer
关键词
肺癌
循环肿瘤细胞
肺癌诊断
肺癌预后评估
Lung cancer
Circulating tumor cell
Lung cancer diagnosis
Prognosis of lung cancer
