摘要
目的研究华蟾素胶囊联合奥沙利铂+卡培他滨治疗晚期胃癌的效果及对患者免疫功能的影响。方法70例晚期胃癌患者随机分为观察组和对照组,对照组患者给予奥沙利铂+卡培他滨化疗,观察组患者在对照组治疗的基础上给予华蟾素胶囊治疗。治疗6个周期后,行影像学检查评估肿瘤大小;采用流式细胞仪测定患者CD4^+、CD8^+、CD4^+/CD8^+水平变化;按照WHO抗癌药物急性及亚急性毒性反应分级标准评价不良反应;按照卡氏评分(Karnofsky)评估患者生活质量。结果治疗6个周期后,观察组临床总有效率显著高于对照组(48. 57%vs. 34. 29%,P <0. 05)。2组治疗前CD4^+、CD8^+、CD4^+/CD8^+比值无统计学差异(P> 0. 05);治疗后,对照组CD4~^+、CD8^+、CD4^+/CD8^+比值显著降低(P <0. 05),而观察组未明显降低,且显著高于对照组(P <0. 05)。观察组不良反应发生率显著低于对照组(P <0. 05);观察组患者生活质量总改善率显著高于对照组(85. 71%vs. 60. 00%,P <0. 05)。结论华蟾素胶囊联合化疗可以改善晚期胃癌患者免疫功能,减少化疗引起的不良反应,提高患者生活质量。
Objective To study the effect of Huachansu capsule combined with oxaliplatin plus capecitabine in the treatment of advanced gastric cancer and its effect on immune function. Methods Seventy patients with advanced gastric cancer were randomly divided into observation group and control group.Patients in the control group were treated with oxaliplatin plus capecitabine.Patients in the observation group were treated with Huachansu capsule on the basis of the control group.After 6 cycles of treatment,the tumor size was evaluated by imaging examination;the changes of CD4^+,CD8^+ and CD4^+/CD8^+ levels were measured by flow cytometry;the adverse reactions were evaluated according to the classification criteria of acute and subacute toxicity of WHO anticancer drugs;Karnofsky assesses the quality of life of patients. Results After 6 cycles of treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group (48.57% vs.34.29%, P <0.05).There was no significant difference in the ratio of CD4^+,CD8^+ and CD4^+/CD8^+ between the two groups ( P >0.05).After treatment,the ratio of CD4^+,CD8^+ and CD4^+/CD8^+ in the control group was significantly lower ( P <0.05),but the observation group did not decrease significantly.And significantly higher than the control group ( P <0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group ( P <0.05).The overall improvement rate of quality of life in the observation group was significantly higher than that in the control group (85.71% vs.60.00%, P <0.05). Conclusion Huayusu capsule combined with chemotherapy can improve the immune function of patients with advanced gastric cancer,reduce the adverse reactions caused by chemotherapy,and improve the quality of life.
作者
闫立辉
盛春晓
苏海刚
杨宇
徐野
佟欣宇
曲丹
YAN Lihui;SHENG Chunxiao;SU Haigang(The 4th Hospital of Fushun City,Fushun,113123)
出处
《实用癌症杂志》
2019年第5期821-824,共4页
The Practical Journal of Cancer
关键词
华蟾素胶囊
晚期胃癌
免疫功能
疗效
Cinobufacini capsule
Advanced gastric cancer
Immune function
Curative effect
