摘要
目的:探讨P53、配对盒基因8抗体(pairing box gene 8 antibody,PAX8)和钙网膜蛋白(calcium omentum protein,Calretinin)在卵巢肿瘤组织与输卵管上皮中的表达及其与卵巢癌起源的相关性。方法:采用免疫组织化学检测63份输卵管上皮和卵巢肿瘤组织中P53,PAX8和Calretinin的表达,分析其表达水平与卵巢肿瘤分级的关系。结果:在卵巢癌中,卵巢肿瘤组织P53或PAX8阳性与高级别浆液性癌相关,而Calretinin阳性与低级别浆液性癌相关,差异具有统计学意义(均P<0.05)。卵巢肿瘤组织PAX8和Calretinin联合表达与卵巢肿瘤级别相关,差异具有统计学意义(P<0.05);卵巢肿瘤组织P53和Calretinin联合表达与卵巢肿瘤级别相关,差异具有统计学意义(P<0.05);卵巢肿瘤组织P53和PAX8联合表达与卵巢肿瘤级别相关,差异具有统计学意义(P<0.05)。输卵管上皮P53表达与卵巢癌恶性程度相关,差异具有统计学意义(P<0.05)。输卵管上皮恶性病变与高级别浆液性癌相关,输卵管上皮正常或非典型增生与低级别浆液性癌相关,差异具有统计学意义(均P<0.05)。结论:联合检测P53,PAX8和Calretinin对卵巢癌级别的判定具有辅助作用,输卵管上皮中HE形态和P53的表达对诊断卵巢癌的级别具有辅助作用。
Objective:To explore the role of P53,pairing box gene 8 antibody(PAX8),and calcium omentum protein(Calretinin)in the origin of epithelial ovarian cancer.Methods:A total of 63 tissue samples of ovarian tumor and fallopian tubes were collected.Immunohistochemistry methods were used to analyze the expression of P53,PAX8,and Calretinin.The relationship between these protein levels and the classification of ovarian tumors was evaluated.Results:In epithelial ovarian cancer,the P53 or PAX8 was correlated with the occurrence of highgrade carcinoma,while the calretinin was correlated with the occurrence of low-grade carcinoma(P<0.05).The combination of PAX8 with Calretinin was correlated with the grade of ovarian tumor(P<0.05).The combination of P53 with Calretinin was correlated with the grade of tumor(P<0.05).The combination of P53 with PAX8 was correlated with the grade of tumor(P<0.05).The expression of P53 in fallopian tubes was correlated with the malignant degree of epithelial ovarian cancer(P<0.05).The degree of fallopian tube lesions in patients with ovarian cancer was correlated with epithelial ovarian cancer.The malignant lesions of tubal epithelium was correlated with highgrade carcinoma,while the normal or atypical hyperplasia of tubal epithelium was correlated with low-grade carcinoma(P<0.05).Conclusion:P53 and Calretinin combined with PAX8 show a synergistic effect on the differentiation of epithelial ovarian cancer grade.The morphology of HE and the expression of TP53 in the fallopian tube epithelium play an auxiliary role in the diagnosis of epithelial ovarian cancer.
作者
袁亦姝
朱薇
龚光辉
蒋晶
王祎璇
吴晓英
YUAN Yishu;ZHU Wei;GONG Guanghui;JIANG Jing;WANG Yixuan;WU Xiaoying(Department of Pathology,Xiangya Hospital,Central South University,Changsha 410008;Department of Pathology,School of Basic Medical Science,Central South University,Changsha 410013,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2019年第5期528-534,共7页
Journal of Central South University ：Medical Science
关键词
卵巢癌
输卵管上皮
起源
肿瘤级别
ovarian carcinoma
fallopian tubal epithelium
origin
tumor grade
