摘要
眼表疾病的发病机制复杂多样,其中角结膜细胞外基质(ECM)代谢失衡是其发病的重要原因之一。转化生长因子-β1(TGF-β1)/Smads作为调控ECM产生、转归及代谢平衡的主要信号通路,参与了本病的发生发展。本文将主要从该通路与眼表疾病的关系方面做一综述,以期为眼表疾病的治疗提供新的依据。
The pathogenesis of ocular surface diseases is complex and diverse, among which the imbalance of ECM is one of the important causes. Transforming growth factor -β1 (TGF-β1)/Smads is involved in the development of the disease as a major signaling pathway regulating the production, outcome and metabolic balance of ECM. The relationship between this pathway and ocular surface diseases will be reviewed in this paper, which will provide a new basis for the treatment of ocular surface diseases.
作者
王亚卉
李青松
符之瑄
桂炎香
张斌
WANG Yahui;LI Qingsong;FU Zhixuan;GUI Yanxiang;ZHANG Bin(Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China)
出处
《中国医药导报》
CAS
2019年第13期50-53,65,共5页
China Medical Herald
基金
上海市医学重点专科建设计划项目(ZK2015A20)
上海市普陀区卫生系统自主创新科研资助项目(ptkwws201703)
上海中医药大学预算内项目(18WK106)
上海市普陀区中心医院院级科研课题(2016301A)
