摘要
转录因子EB(transcription factor EB,TFEB)是一种对骨骼肌糖、脂代谢、线粒体生物发生发挥作用的蛋白质,因其在物质代谢和生物发生等表型变化中表现出的重要作用而备受生物科学领域的关注。在正常生理状态下,TFEB主要存在于细胞浆中,并处于失活状态;在急性运动和耐力运动时发生转位,从细胞浆进入细胞核,诱导线粒体生物发生;参与调控糖代谢相关的一系列信号途径如葡萄糖转运体基因的表达、葡萄糖的摄取和利用、糖原合成等;还可调节脂肪酸氧化和氧化磷酸化等相关基因的表达,其结果增强了机体的运动能力。梳理TFEB在运动适应骨骼肌表型变化中的可能作用机制,为运动防治糖尿病、高脂血症和代谢综合症等胰岛素抵抗相关疾病的发生、发展提供新靶点,同时也可能为运动适应骨骼肌表型变化分子机制的研究提供新视角。
Transcription factor EB(TFEB) is a protein which acts on the glucose and lipid metabolism and mitochondrial biogenesis in skeletal muscle. It has received much attention in the research area of biological sciences because of its important role in phenotypic changes of metabolism and biogenesis. Under normal physiological conditions, TFEB is inactive and mainly exists in the cytoplasm. It will be transferred from cytoplasm to the nucleus under acute or endurance exercise stress, this transformation induces mitochondrial biogenesis and participates in a series of signaling pathways to regulate glucose metabolism such as glucose transporter gene expression, glucose uptake and utilization, glycogen synthesis. Moreover, the genes referring to fatty acid oxidation and oxidative phosphorylation will be regulated as well and resulting in an improvement in exercise capacity. This paper discussed the molecular mechanisms of TFEB in exercise adaptation to skeletal muscle phenotype changes, in order to find new targets for the prevention and treatment of insulin resistance-related diseases such as diabetes, hyperlipidemia and metabolic syndrome. Meanwhile, it also provides a new perspective of the researches related to the molecular mechanism of exercise induced adaptation in skeletal muscle.
作者
王平
LI Chunguang
丁树哲
WANG Ping;DING Shuzhe(School of Physical Education and Health, Hangzhou Normal University, Hangzhou 311121, China;National Institute of Complementary Medicine, Western Sydney University, Sydney 2751, Australia;Key Laboratory of Adolescent Health Assessment and Exercise Intervention Ministry of Education, East China Normal University, Shanghai 200241, China;School of Physical Education and Health, East China Normal University, Shanghai 200241, China)
出处
《体育科学》
CSSCI
北大核心
2019年第5期81-87,共7页
China Sport Science
基金
国家自然科学基金资助项目(31671241)
杭州师范大学博士启动金(PE13002004028)
关键词
转录因子EB
运动适应
骨骼肌
表型变化
transcription factor EB
exercise adaptation
skeletal muscle
phenotype changes
