摘要
目的:探讨大黄附子汤联合西医基础治疗对危重脓毒症患者症状体征改善和胃肠功能改善情况的治疗效果。方法:选取危重脓毒症患者100例,采用随机数字表法分为对照组和观察组,各50例。两组均给予抗感染、营养支持和脏器支持,对照组在常规治疗基础上给予莫沙必利片,观察组在此基础上给予大黄附子汤治疗。观察两组疗效指数、中医证候总积分、APACHEⅡ评分和胃肠功能障碍评分,并对用药的安全性进行观察。结果:对照组治疗后的总有效率60%显著低于观察组86%,两组比较差异具有统计学意义(P<0.05)。治疗后对照组、观察组中医证候总积分分别为(13.34±5.21)分、(6.55±6.24)分,APACHEⅡ评分分别为(15.43±8.12)分、(10.54±6.03)分,与治疗前比较,差异均有统计学意义(P<0.05),且观察组评分显著优于对照组(P<0.05)。对照组治疗前胃肠功能障碍评分对照组为(2.34±0.24)分,观察组为(2.26±0.29)分,均显著优于治疗前(P<0.05),且观察组评分显著优于对照组(P<0.05)。另外两组患者常规基础检查均未见明显异常。结论:大黄附子汤联合西医基础治疗在治疗脓毒症方面比传统的西医治疗效果更显著,可有效改善患者的临床症状和胃肠功能障碍情况,降低脓毒症的严重程度。
Objective:To explore the therapeutic effect of Dahuang Fuzi prescription combined with western medicine on the improvement of symptomatic signs and improvement of gastrointestinal function in patients with severe sepsis.Methods:100 patients using the random number table method were divided into control group and observation group.50 cases with two groups of patients were given anti-infection,nutritional support,and organ support therapy,the control group on the basis of conventional treatment given moser will benefit treatment,observation group in the control group on the basis of given rhubarb aconite decoction,observed the curative effect of two groups of patients after treatment index,the total score of syndromes,the APACHE Ⅱ grade and gastrointestinal dysfunction,and the safety of medication.Results:The total effective rate after treatment in the control group 60% was significantly lower than that in the observation group 86%.The TCM syndrome scores of the control group and the observation group were (13.34±5.21) scores,(6.55±6.24) scores,and the APACHEII scores were (15.43±8.12) scores and (10.54±6.03) scores,respectively.The difference was significant (P<0.05).The observation group score was significantly better than the control group (P<0.05).Gastrointestinal dysfunction score in control group was (2.34±0.24) scores,the observation group was (2.26±0.29) scores,which was significantly better than before treatment (P<0.05),and the observation group score was excellent.There were no significant abnormalities in the routine basic examination indicators during the treatment period.Conclusion:Dahuang Fuzi prescription basic combined western medicine therapy in the treatment of sepsis is more significant than conventional western medicine treatment effect,can effectively improve the patient's clinical symptoms and gastrointestinal dysfunction,improve the treatment effect,reduce the severity of the sepsis,worthy of clinical popularization and application.
作者
李军
LI Jun(Department of Intensive Medicine,Baoji Hospital of Traditional Chinese Medicine,Baoji 721000)
出处
《陕西中医》
2019年第6期718-721,共4页
Shaanxi Journal of Traditional Chinese Medicine
关键词
大黄附子汤
莫沙必利
脓毒症
危重症
胃肠功能障碍
临床研究
Dahuang Fuzi prescription
Moshabili
Sepsi
Critical symptoms
Gastrointestinal dysfunction
C1inical research
