摘要
目的:分析肾益康胶囊联合氯沙坦钾治疗慢性肾炎对患者肾功能和凝血功能的影响。方法:选取慢性肾炎患者114例,根据治疗方法分为对照组(口服氯沙坦钾治疗)和观察组(肾益康胶囊联合氯沙坦钾治疗),分析两组患者治疗后的临床疗效。结果:两组治疗前中医症状积分组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后乏力(1.21±0.54)分、肢体浮肿(1.53±0.53)分、腰部酸痛(1.19±0.61)分、胃脘胀满(1.34±0.72)分、食少纳呆(1.32±0.73)分,均低于对照组(P<0.05)。两组治疗前凝血指标、肾功能指标、血管性血友病因子、白细胞介素-18、可溶性血管内皮细胞蛋白C受体水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后凝血酶原时间、活化部分凝血活酶时间、凝血酶-Ⅲ水平高于对照组,纤维蛋白原、D-二聚体、24h尿蛋白、vWF、IL-18、sEPCR水平均低于对照组,但血清尿素氮和血清肌酐水平与对照组比较,差异不具有统计学意义(P>0.05)。结论:肾益康胶囊联合氯沙坦钾治疗慢性肾炎可减轻患者临床症状,改善凝血指标,减少蛋白尿,保护肾功能。
Objective:To analyze the effect of Shenyikang capsule combined with losartan potassium on renal function and coagulation function in patients with chronic nephritis.Methods: 114 patients with chronic nephritis admitted were divided into two groups:control group (treated with oral losartan potassium) and observation group (Shenyikang capsule combined with losartan potassium therapy).To analyze the clinical effect of two groups of patients after treatment.Results:There was no significant difference between the two groups before treatment (P>0.05).In the observation group,the scores of fatigue (1.21±0.54),limb edema (1.53±0.53),pain in the waist (1.19±0.61),stomachache (1.34 ±0.72) and stomachache were(1.32±0.73).The scores of above were lower than those of the control group (P<0.05).The indexes of coagulation,renal function,von Willebrand factor,interleukin-18 and soluble vascular endothelial cell protein C receptor were compared between the two groups before treatment.The difference was not statistically significant (P>0.05).The levels of APTT,thrombin Ⅲ,fibrinogen,D- dimer,24 hours urine protein and vWF,in the observation group were higher than those in the control group after treatment with prothrombin time,activation and partial thromboplastin time.The level of IL-18,sEPCR was lower than that of the control group,but The levels of serum urea nitrogen and serum creatinine were not significantly different from those of the control group (P>0.05).Conclusion: Shenyikang capsule combined with losartan potassium in the treatment of chronic glomerulonephritis can relieve clinical symptoms improve coagulation index reduce proteinuria and protect renal function.
作者
李楠
夏松青
张勇慧
姚雷
LI Nan;XIA Songqing;ZHANG Yonghui(Henan Yumei Nephropathy Hospital,Hebi 456750)
出处
《陕西中医》
2019年第6期760-763,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省医学科技攻关计划项目(2016043901)
关键词
肾益康胶囊
氯沙坦钾
慢性肾炎
肾功能
凝血功能
血管性血友病因子
Shenyikang capsule
Losartan potassium
Chronic nephritis
Renal function
Coagulation function
Von willebrand factor
