摘要
目的探究等渗对比剂与低渗对比剂在冠心病介入治疗中的应用效果及安全性。方法选取我院收治的73例冠心病介入治疗患者,根据术中应用对比剂的不同分为低渗组(n=36,低渗对比剂)和等渗组(n=37,等渗对比剂)。比较两组患者对比剂的用量、治疗前、后的肾功能指标、治疗后对比剂肾病的发生风险及发生率。结果低渗组的对比剂用量与等渗组的对比剂用量比较,差异无统计学意义(P>0.05)。两组患者治疗后第3天的Scr水平明显高于治疗前和治疗后第1天(P<0.05),且等渗组治疗后第3天的Scr水平显著低于低渗组同期水平(P<0.05);两组患者治疗后第1、3天的eGFR水平显著低于治疗前(P<0.05),治疗后第3天的eGFR水平显著低于治疗后第1天(P<0.05),且等渗组患者治疗后第1、3天的eGFR水平显著高于低渗组同期水平(P<0.05)。等渗组患者治疗后对比剂肾病的风险明显低于低渗组患者(P<0.05)。等渗组患者对比剂肾病发生率显著低于低渗组(P<0.05)。结论冠心病介入治疗中应用等渗对比剂对患者肾功能的影响小,可降低患者治疗后对比剂肾病的风险和发生率,安全性高。
Objective To explore the application effect and safety of isotonic and hypotonic contrast media in interventional therapy of coronary heart disease. Methods Seventy-three patients with coronary heart disease treated by interventional therapy in our hospital were divided into hypoosmotic group (n=36, hypotonic contrast media) and isotonic group (n=37, isotonic contrast media) according to different application of contrast media during operation. The dosage of contrast medium, renal function indexes before and after treatment, the risk and incidence of contrast -induced nephropathy after treatment were compared between the two groups. Results There was no significant difference in the dosage of contrast media between the hypotonic group and isotonic group (P>0.05). The level of Scr of the two groups on the 3rd day after treatment was significantly higher than that before treatment and on the 1st day after treatment (P<0.05), and the level of Scr in the isotonic group on the 3rd day after treatment was significantly lower than that in the hypotonic group at the same time (P<0.05). The levels of eGFR of the two groups on the 1st and 3rd day after treatment were significantly lower than those before treatment (P<0.05), and the level of eGFR on the 3rd day after treatment were significantly lower than that on the 1st day after treatment (P<0.05), and the levels of eGFR in the isotonic group on the 1st and 3rd day after treatment were significantly higher than those in the hypotonic group at the same time (P<0.05). The risk of contrast-induced nephropathy in the isotonic group was significantly lower than that in the hypotonic group (P<0.05). The incidence of contrast-induced nephropathy in the isotonic group was significantly lower than that in the hypotonic group (P<0.05). Conclusion The application of isotonic contrast media in interventional therapy of coronary heart disease has little effect on renal function, which can reduce the risk and incidence of contrast-induced nephropathy after treatment, with high safety.
作者
马涛
杨瑞金
MA Tao;YANG Rui-jin(No.987 Hospital of the PLA, Baoji 721000, China)
出处
《临床医学研究与实践》
2019年第16期43-45,共3页
Clinical Research and Practice
关键词
冠心病
经皮冠状动脉介入
等渗对比剂
低渗对比剂
coronary heart disease
percutaneous coronaryintervention
isotonic contrast media
hypotonic contrast media
