摘要
Krüppel样因子5(KLF5)是一种能与DNA结合的锌指转录调节因子,其在乳腺癌、前列腺癌、结直肠癌和肺癌等多种恶性肿瘤中的作用具有环境依赖性。微RNA和长链非编码RNA可以调控KLF5的表达。同时KLF5也可以调控众多的下游靶基因的表达。本文主要介绍了KLF5在恶性肿瘤中的作用,也分析了在不同的细胞状态下通过调节KLF5蛋白的水平而影响下游基因表达的机制差异。深入研究这些差异性或能进一步揭示KLF5在肿瘤发生发展中的作用规律。
Krüppel-like factor 5(KLF5)is a DNA-binding transcriptional regulator which plays an important role in most tumors.The functions of KLF5 are context-dependent in breast cancer,prostate cancer,colorectal cancer and lung cancer.It can be regulated by microRNAs and non-coding RNAs.It can also regulate the expression of many downstream target genes.This article presents the differential roles of KLF5 in different cancers,and the mechanisms by which these differences are affected through the regulation of KLF5 protein function in response to different cellular states and the direct effect on downstream genes expression.Exploring these differences is likely to be important in discoveries and new research ideas about KLF5.
作者
李响
宁倩
戴诗琴
唐圣松
LI Xiang;NING Qian;DAI Shiqing;TANG Shengsong(Learning Key Laboratory for Pharmacoproteomics of Hunan Province,Institute of Pharmacy&Pharmacology,University of South China,Hengyang 421001,Hunan,China;Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System,Hunan University of Medicine,Huaihua 418000,Hunan,China)
出处
《中南医学科学杂志》
CAS
2019年第3期225-229,共5页
Medical Science Journal of Central South China
基金
湖南省科技计划重点资助项目(2017SK2183)
湖南省自然科学基金(2019JJ50416)
