摘要
目的分析2型糖尿病视网膜病变患者及2型糖尿病未伴发视网膜病变患者血糖、血压、病程、血脂、肾功能等指标水平,探讨影响糖尿病患者视网膜病变的因素。方法2型糖尿病患者根据是否伴发眼底病变分为两组:糖尿病视网膜病变组(DR组)和糖尿病未伴发视网膜病变组(NDR组)。采集患者病史记录中的血压、病程等,应用全自动生化分析仪分别检测两组患者的空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白a(Lpa)、载脂蛋白E(ApoE)、游离脂肪酸(NEFA)、尿素(BUN)、肌酐(Cr)、尿酸(UA)、餐后2h血糖(2hPG)水平;采集患者乙二胺四乙酸抗凝全血,应用高压液相色谱法测定两组患者糖化血红蛋白(HbA1c)水平;留取患者晨尿,应用免疫比浊仪测定尿微量清蛋白(m-ALB)水平。结果DR组的病程、FPG、卧位舒张压、TC、HDL-C、LDL-C、ApoA1、m-ALB水平明显高于NDR组(P<0.05),其余指标在两组间比较,差异无统计学意义(P>0.05)。结论糖尿病患者病程延长,以及FPG、卧位舒张压、TC、HDL-C、LDL-C、ApoA1、m-ALB水平增高是糖尿病伴发视网膜病变的危险因素。
Objective To analyze the levels of blood sugar,blood pressure,course of disease,blood lipids and renal function in the patients with type 2 diabetic retinopathy(T2DN)and those with type 2 diabetes mellitus(T2DM)without complicating retinopathy,and to explore the factors influencing diabetic retinopathy in diabetic patients.Methods The type 2 diabetic patients were divided into the two groups according to whether complicating retinopathy:the diabetic retinopathy group(DR)and diabetic non-diabetic retinopathy group(NDR).The blood pressure and course of disease in the medical record were collected.The levels of fasting blood glucose(FPG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),lipoprotein a(Lpa)and apolipoprotein E(ApoE),free fatty acids(NEFA),urea(BUN),creatinine(Cr),uric acid(UA)and postprandial 2 h blood glucose(2 h PG)were detected by using the automatic biochemical analyzer.The anticoagulant whole blood with EDTA was collected and the level of HbA1c was determined by high performance liquid chromatography,the urinary microalbumin(m-ALB)was measured by immunoturbidimetry in the morning urine of the patients.Results The disease course,FPG,diastolic pressure at recumbent position,TC,HDL-C LDL-C ApoA1 and m-ALB levels in the DR group were significantly higher than those in the NDR group(P<0.05).The remaining indicators had no statistically significant difference between the two groups(P>0.05).Conclusion The disease duration extension,FPG,diastolic pressure at recumbent position,TC,HDL-C,LDL-C,ApoA1 and m-ALB levels increase are the risk factors for diabetes complicating retinopathy.
作者
李磊
孔倩倩
王丽
余汉忠
LI Lei;KONG Qianqian;WANG Li;YU Hanzhong(Department of Clinical Laboratory,Xuzhou Municipal Third People's Hospital,Xuzhou,Jiangsu 221002,China;Department of Clinical Laboratory,Affiliated Xuzhou Municipal Hospital,Xuzhou Medical University,Xuzhou,Jiangsu 221002,China)
出处
《检验医学与临床》
CAS
2019年第11期1503-1505,1508,共4页
Laboratory Medicine and Clinic
基金
江苏省徐州市科技发展基金项目(KC16SH011)
江苏省徐州市重点研发项目(KC18169)
