摘要
目的:探讨胃肠道手术前应用乌司他丁对患者术后炎性因子、外周血T淋巴细胞亚群等指标的影响。方法:选取于2017年12月至2018年12月就本院治疗的胃肠道手术患者88例为研究对象;并按照随机数字表法,将患者分为对照组与研究组;其中,对照组按常规手术方案术前给予患者5%葡萄糖氯化钠静脉滴注,研究组则于麻醉诱导前给予患者乌司他丁静脉滴注,对比观察术后患者炎性因子与外周血T淋巴细胞亚群变化情况。结果术后对比,研究组术后24h、72h白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)等水平均低于对照组,IL-10水平则高于对照组;同时,CD4^+、CD4^+/CD8^+均高于对照组患者(P<0.05),CD8^+水平与对照组对比差异并无统计学意义(P>0.05)。结论:在胃肠道手术中运用乌司他丁,有助于减轻患者术后炎性反应,增强机体免疫功能,减轻手术对机体的损伤,效果显著。
Objective:To study the effect of Ulinastatin on the postoperative inflammatory factors and peripheral blood T-lymphocyte subsets in patients with gastrointestinal tract operation.Method:From December 2017 to December 2018,88 patients were selected and divided into the control group and the study group.The control group was given 5%glucose and sodium chloride by intravenous drip.The study group was given the patient's Ulinastatin intravenous drip before the induction of anesthesia,and the change of inflammatory factors and T-lymphocyte subsets in peripheral blood was compared.Results:Compared with the control group,the levels of IL-6,IL-8,TNF-α,and CRP were lower and IL-10,CD4^+,and CD4^+/CD8^+was higher in the study group(P<0.05).There was no significant difference in the level of CD8^+between the two groups(P>0.05).Conclusion:Ulinastatin is used in the gastrointestinal operation,which can help to relieve the inflammatory reaction after the operation of the patient,enhance the immune function of the body,and reduce the damage of the operation to the body.
作者
黄学胜
HUANG Xue-sheng(Jiaozuo District,Jiaozuo City 988 Hospital,Jiaozuo Henan 454003,China)
出处
《药品评价》
CAS
2019年第10期23-25,共3页
Drug Evaluation
关键词
乌司他丁
胃肠道手术
炎性因子
T淋巴细胞亚群
Ulinastatin
Gastrointestinal Surgery
Inflammatory Factors
T Lymphocyte Subsets
