摘要
目的益气润燥汤联合适形调强(intensity-modulated radiotherpy,IMRT)放化疗治疗鼻咽癌患者的临床研究。方法募集2016年1月至2018年5月期间收治的鼻咽癌患者160例,按随机数字表法分为对照组(IMRT放化疗)80例,治疗组(中药方剂配合IMRT放化疗)80例。比较两组患者术后总有效率、功能状态评分(Karnofsky,KPS)、体质量变化、不良反应症状等。结果两组患者近期疗效比较,对照组总有效率为52.5%,治疗组总有效率为85.0%,两组间差异有统计学意义(P<0.05);治疗组Karnofsky评分及体质量方面的改善情况优于对照组,两组比较差异均有统计学意义(P<0.05);治疗组与对照组骨髓抑制反应比较:(χ^2=0.084,P=0.235);口腔黏膜反应比较:(χ^2=0.255,P=0.000);消化道情况比较:(χ^2=0.205,P=0.000);食少纳呆的比较:(χ^2=33.577,P=0.000)。结论益气润肺汤有助于改善患者IMRT放疗的预后,对放疗过程中产生的不良反应有明显的防治效果,值得在临床推广应用。
Objective To explore the clinical effects on nasopharyngeal carcinoma treated with yiqi runzao decoction and intensity-modulated radiotherapy(IMRT)in the patients.Methods From January 2015 through to May 2018,160 patients with nasopharyngeal carcinoma were recruited.They were divided into a control group(IMRT,80 cases)and a treatment group(herbal formula and IMRT,80 cases)according to random number table.The total effective rate,Karnofsky(KPS)score,body mass and adverse reaction were compared between the two groups.Results The short-term total effective rate was 52.5%in the control group and was 85.0%in the treatment group,indicating the significant difference in comparison(P<0.05).The improvements of KPS score and body mass in the treatment group were better than the control group,indicating the significant difference(both P<0.05).In comparison of bone marrow inhibition reaction between the treatment group and the control group,χ^2=0.084,P=0.235;regarding the comparison of oral mucosal reaction,χ^2=0.255,P=0.000;regarding the respiratory tract condition,χ^2=0.205,P=0.000,regarding poor appetite,χ^2=33.577,P=0.000.Conclusion Yiqi runzao decoction contributes to the prognosis of IMRT and effectively prevents from the adverse reactions of radiotherapy.Hence,this therapy deserves to be promoted in clinical application.
作者
柳吉玲
劳国平
黄韵
冯萍
LIU Ji-ling;LAO Guo-ping;HUANG Yun;FENG Ping(Wuzhou Red Cross Society Hospital,Wuzhou Guangxi 543002)
出处
《世界中西医结合杂志》
2019年第5期663-666,共4页
World Journal of Integrated Traditional and Western Medicine
基金
梧州市科学研究与技术开发计划项目(201502034)
关键词
益气润燥汤
IMRT放化疗
鼻咽癌
预后差异
Yiqi Runzao Decoction
IMRT
Nasopharyngeal Carcinoma
Prognosis Difference
