摘要
目的探讨依那普利联用叶酸治疗H型高血压的临床疗效及对血管内皮功能的影响。方法 180例H型高血压患者,按照治疗方法不同分为对照组和观察组,各90例。对照组患者采取依那普利治疗,观察组患者采取依那普利联用叶酸治疗。比较两组患者临床疗效;血压变异性指标达到正常时间;治疗前后患者血栓调节蛋白、血清同型半胱氨酸、一氧化氮以及血管内皮素水平;不良反应发生情况。结果观察组患者总有效率为88.89%,显著高于对照组的75.56%,差异具有统计学意义(P<0.05)。治疗前,两组患者血栓调节蛋白、血清同型半胱氨酸、一氧化氮以及血管内皮素水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者血栓调节蛋白、血清同型半胱氨酸、一氧化氮以及血管内皮素水平均明显优于对照组,差异具有统计学意义(P<0.05)。观察组患者血压变异性指标达到正常时间为(9.11±1.42)d,明显短于对照组的(14.42±2.11)d,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论依那普利联用叶酸治疗H型高血压的疗效显著,可更好改善血栓调节蛋白、血清同型半胱氨酸、一氧化氮以及血管内皮素水平,且具有安全性,值得临床应用推广。
Objective To discuss the clinical efficacy of enalapril combined with folic acid in the treatment of type H hypertension and its influence on vascular endothelial function. Methods A total of180 type H hypertension patients were divided by different treatment methods into control group and observation group, with 90 cases in each group. The control group was treated with enalapril, and the observation group was treated with enalapril and folic acid. Comparison were made on clinical efficacy, time for blood pressure variability reaching normal time, thrombomodulin, serum homocysteine, nitric oxide and vascular endothelin level before and after treatment, and the occurrence of adverse reactions between the two groups. Results The observation group had significantly higher total effective rate as 88.89% than 75.56% in the control group, and the difference was statistically significant(P<0.05). Before treatment, both groups had no statistically significant difference in thrombomodulin, serum homocysteine, nitric oxide and vascular endothelin(P>0.05). After treatment, the observation group had obviously better thrombomodulin, serum homocysteine, nitric oxide and vascular endothelin than the control group, and their difference was statistically significant(P<0.05). The observation group had obviously shorter blood pressure variability reaching normal time as(9.11±1.42) d than(14.42±2.11) d in the control group, and the difference was statistically significant(P<0.05). Both groups had no statistically significant difference in incidence of adverse reactions(P>0.05). Conclusion Combination of enalapril and folic acid shows significant effect in the treatment of H-type hypertension, and it can better improve thrombomodulin,serum homocysteine, nitric oxide and vascular endothelin level. It is safe and worthy of clinical application and promotion.
作者
林飞鸿
伍瑚
李超强
LIN Fei-hong;WU Hu;LI Chao-qiang(Department of Internal Medicirte-Neurology,Guangdong Wuchuan People,s Hospital,Wuchuan 524500,China)
出处
《中国实用医药》
2019年第14期6-7,共2页
China Practical Medicine
关键词
依那普利
叶酸
H型高血压
临床疗效
血管内皮功能
影响
Enalapril
Folic acid
Type H hypertension
Clinical efficacy
Vascular endothelial function
Influence
