摘要
目的探讨笑气(氧化亚氮,N2O)滥用致神经系统损害的临床特点、治疗及预后方法收集8例N2O滥用患者的临床资料,随访评估疗效及预后。结果8例患者均为19-26岁的青年;临床表现类似于脊髓亚急性联合变性(SCD)的症状;实验室检查多伴有高同型半胱氨酸血症,磁共振检查可见脊髓后索脱髓鞘病变,电生理检查可有以下肢为主的感觉运动性周围神经病表现,神经心理学测试显示认知受损;停止接触N2O和大剂量维生素B12补充治疗后上述症状均有不同程度的改善:结论N2O滥用可致中枢及周围神经系统受损,补充大剂量维生素B12是有效的治疗手段。
Objective To explore the clinical features, treatment and prognosis of neurologicid damage caused by nitrous oxide ( N2O) abuse. Methods The clinical data of 8 patients with N2O abuse were collected, and the efficacy and prognosis were evaluated after follow - up. Results These 8 patients were all young people aged 19-26 years. Their clinical manifestations were similar to those of subacute combined degeneration of the spinal cord. Laboratory examinations were mostly accompanied hyperhomocysteinemia. Magnetic resonance imaging ( MRI) examination showed demyelinating lesions in the posterior cord of the spinal cord. Electrophysiological examination showed sensorimotor peripheral neuropathy mainly in the lower limbs. Neuropsychological tests showed impairment of cognition. Different degrees of improvement of the above symptoms were achieved after the cessation of N2O exposure with a high close of vitamin BP supplementation. Conclusions N2O abuse may cause the damage of the central and peripheral nervous system. Supplementing large doses of vitamin B12 is an effective treatment.
作者
王瑞
梁娜娜
孙亚丽
耿子旸
马晨晨
丁红梅
朱士光
董瑞国
WANG Rui;LIANG Nana;SUN Yali;GENG Ziyang;MA Chenchen;DING Hongmei;ZHU Shiguang;DONG Ruiguo(Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu 221002 , China;Department of Neurology,the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002)
出处
《徐州医科大学学报》
CAS
2019年第5期350-353,共4页
Journal of Xuzhou Medical University
