摘要
目的分析下肢动脉硬化闭塞症患者应用西洛他唑联合前列地尔治疗的效果。方法从该院2015年2月—2017年2月间收治的下肢动脉硬化闭塞症患者中,方便选取出符合标准的患者100例,通过随机数字模拟法,将其分成单一用药组和联合用药组。单一用药组单用前列地尔药物治疗,联合用药组用前列地尔、西洛他唑进行治疗。对比两组患者的血液流动学指标、动脉硬化指标、治疗有效率。结果经过治疗后,检测两组患者血液流变学指标,单一治疗组患者的血浆粘度、红细胞变形指数、红细胞聚集指数、血细胞比容,分别是(1.17±0.20)mPa·s、(0.61±0.10)、(5.60±0.69)、(0.46±0.10)分;联合组分别是(0.93±0.07)mPa·s、(0.45±0.07)、(4.86±0.69)、(0.36±0.04)%,明显可以看出联合用药组的表现更好,与单一用药组比较差异有统计学意义(t=8.009、9.269、5.362、656.5P<0.05);比较治疗之后两个小组患者的动脉硬化指标,单一治疗组患者的足背动脉血流量、TBI、ABI,分别是(1.05±0.31)m(s·cm^2)、(0.53±0.22)、(1.14±0.29);联合组分别是(0.87±0.17)m(s·cm^2)、(0.81±0.32)、(1.35±0.35),联合用药组与单一用药组进行比较,差异有统计学意义(P<0.05);联合用药组治疗效果(94.00%)显著高于单一用药组(80.00%),差异有统计学意义(χ^2=4.3324,P<0.05)。结论西洛他唑、前列地尔,联合应用在治疗下肢动脉硬化闭塞症患者中,表现良好,有助于改善患者血液流变学指标和动脉硬化指标,提高治疗总有效率,值得推广研究。
Objective To analyze the effect of cilostazol combined with alprostadil in patients with lower extremity arteriosclerosis obliterans. Methods From February 2015 to February 2017 the patients with lower extremity arteriosclerosis obliterans admitted to our hospital, 100 patients who met the criteria were convenient selected and divided into single drug group and combined drug group by random number simulation. The single drug group was treated with alprostadil alone, and the combination group was treated with alprostadil and cilostazol. Blood flow indicators, arteriosclerosis indicators, and treatment effectiveness were compared between the two groups. Results After treatment, the hemorheology indexes of the two groups were measured. The plasma viscosity, red blood cell deformation index, erythrocyte aggregation index and hematocrit of the single treatment group were (1.17±0.20)mPa·s,(0.61±0.10),(5.60±0.69),(0.46±0.10)%;the combined group were (0.93±0.07)mPa·s,(0.45±0.07),(4.86±0.69),(0.36±0.04)%. It was obvious that the combination group performed better, compared with the single drug group, the difference was statistically significant(t=8.009、9.269、5.362、656.5 P<0.05). After comparing the two groups of patients Arteriosclerosis index, the blood flow of the dorsal artery in the single treatment group, TBI, ABI were (1.05±0.31)m(s·cm^2),(0.53±0.22),(1.14±0.29), respectively;and the combined group of (0.87±0.17)m(s·cm^2),(0.81±0.32),(1.35±0.35). There was a statistically significant difference between the combination group and the single drug group (P<0.05). Combined drug treatment group (94.00%) was significantly higher than single drug group (80.00%), between the groups, the difference was statistically significant(χ^2=4.332 4,P<0.05). Conclusion Cilostazol and alprostadil are effective in the treatment of lower extremity arteriosclerosis obliterans, which can improve the blood rheology index and arteriosclerosis index and improve the total effective rate of treatment. It is worthy of promotion.
作者
牛敏
孙玲玲
王太行
NIU Min;SUN Ling-ling;WANG Tai-hang(Department of Surgery,Jiyang County Hospital of Traditional Chinese Medicine,Jinan,Shandong Province,251400 China)
出处
《中外医疗》
2019年第11期136-138,共3页
China & Foreign Medical Treatment
关键词
下肢动脉硬化闭塞症
西洛他唑
前列地尔
效果
Lower extremity arteriosclerosis obliterans
Cilostazol
Alprostadil
Effect
