摘要
目的:探索不同肿瘤标志物联合检测对原发性肝癌的诊断效能,为临床诊断提供参考依据。方法:收集来我院就诊的临床诊断为原发性肝癌的患者72例作为观察组,诊断为良性肝病的患者65例作为良性肝病组,80例健康体检者作为健康对照组,所有对象采用化学发光法测定肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原-199(CA199)、糖类抗原-125(CA125)和糖类抗原-153(CA153)的含量,然后对单组患者的5种肿瘤标志物的检测结果、各指标对各组检测阳性率进行比较,并对不同肿瘤标志物单独检测与联合检测原发性肝癌的诊断价值分析。结果:观察组AFP、CA199和CA153的值高于良性肝病组,AFP、CEA、CA199、CA125和CA153的值高于健康对照组,良性肝病组的CA199和CA125的值高于健康对照组,差异具有统计学意义(P<0.05);AFP、CEA、CA199和CA153对观察组的检测阳性率高于良性肝病组,AFP、CEA、CA199和CA125对观察组的检测阳性率高于健康对照组,AFP、CEA、CA199和CA125对良性肝病组的检测阳性率高于健康对照组,差异具有统计学意义(P<0.05);各指标联合检测原发性肝癌的灵敏度为86.4%,特异度为89.2%,正确指数为75.6%,误诊率为13.6%,漏诊率为10.8%,且联合检测比各指标单独检测的正确指数都高。结论:血清肿瘤标志物AFP、CEA、CA199、CA125和CA153联合检测可提高原发性肝癌诊断的灵敏度和特异度,对原发性肝癌有较好的诊断价值。
Objective: To explore the clinical diagnostic value of combined detection of different tumor markers for primary hepatic carcinoma, and to provide the reference for the clinical diagnosis. Methods: 72 patients who were diagnosed with primary hepatic carcinoma were collected as observation group, 65 patients with benign liver disease as benign liver disease group and 80 cases of health examination as healthy control group, the contents of tumor markers alpha fetoprotein(AFP), carcinoembryonic antigen(CEA), carbohydrate antigen-199(CA199), carbohydrate antigen-125(CA125) and carbohydrate antigen-153(CA153) were determined by electrochemiluminescence in all subjects, then the results of five kinds of tumor markers and the positive rates of each index between the two groups were compared, the diagnostic value of separate and combined detection of different tumor markers in primary hepatic carcinoma were analyzed. Results: The values of AFP, CA199 and CA153 in the observation group were higher than the benign liver disease group, the values of AFP, CEA, CA199, CA125 and CA153 in the observation group were higher than the control group, the values of CA199 and CA125 in the benign liver disease group were higher than the control group, the differences were statistically significant ( P <0.05). The positive rates of AFP, CEA, CA199 and CA153 in the observation group were higher than the benign liver disease group, the positive rates of AFP, CEA, CA199 and CA125 in the observation group were higher than the control group, the positive rates of AFP, CEA, CA199 and CA125 in the benign liver disease group were higher than the control group, the differences were statistically significant ( P <0.05). The sensitivity of combined detection of all indicators for primary hepatic carcinoma was 86.4%, specificity, correct index, misdiagnosis rate and missed diagnosis rate were 86.4%, 89.2%, 75.6%, 13.6% and 10.8% respectively, and the combined detection was higher than the correct index of each index. Conclusion: Combined detection of serum tumor markers AFP, CEA, CA199, CA125 and CA153 can improve the sensitivity and specificity of diagnosis of primary hepatic carcinoma, it has better diagnostic value for primary hepatic carcinoma.
作者
高鹏飞
杨豪俊
GAO Peng-fei;YANG Hao-jun(Taihe County People's Hospital in An Hui,Clinical Laboratory,Taihe,Anhui Province,236600,China;The first People's Hospital of Changzhou,Department of Hepatology,Changzhou,Jiangsu Province,213000,China)
出处
《海南医学院学报》
CAS
2019年第11期858-861,866,共5页
Journal of Hainan Medical University
基金
国家自然科学基金资助项目(81700537)~~
关键词
原发性肝癌
肿瘤标志物
诊断价值
联合检测
Primary hepatic carcinoma
Tumor markers
Diagnostic value
Joint detection
