摘要
目的:应用基于体素的形态测量学(VBM)方法评价轻度创伤性脑损伤(mTBI)患者的脑灰质体积变化及其意义。方法:采用PHILIPS1.5T磁共振扫描仪对24例mTBI患者(试验组)和年龄、性别相匹配的24例健康体验者(对照组)进行全脑3DFFET1WI序列扫描。采用SPM8对采集的数据进行预处理,利用VBM软件包对全脑结构进行分析,比较2组受检者灰质体积的差异,并记录临床上mTBI相关症状。结果:与对照组比,试验组左侧扣带回、右侧扣带回、左侧壳核、右侧壳核的灰质体积减小(均P<0.05);右侧额上回、左侧额中回灰质体积增大(均P<0.05)。试验组出现临床症状包括神经功能症状、认知功能下降和行为障碍,其中头痛头晕19例,记忆下降12例,情绪激动9例,注意力不集中8例,肢体不灵活6例,2种及以上症状同时出现15例。结论:VBM揭示了mTBI患者存在部分脑区灰质体积异常,这种异常可能与mTBI患者的临床表现有关。
Objective: To evaluate the volume changes of grey matter and its clinical significance in patients of mild traumatic brain injury with a voxel-based morphometry method. Methods: Whole brain structural images with FFE T1WI were acquired in 24 mTBI patients and 24 mTBI gender-and age-matched healthy controls, SPM8 was used to preprocess the collected data, and VBM software was used to analyze the whole brain structure. The difference of gray matter volume between the two groups was compared by double sample t test. Results: Decreased gray matter volumes were found in some regions including left cingulate gyrus, right cingulate gyrus, left shell nucleus, and right shell nucleusn (all P<0.05). Increased gray matter volumes were found in some regions including upper right frontal gyrus and middle left frontal gyrus. Clinical symptoms included neurologic symptoms, cognitive function and behavior disorders. There were headache and dizziness in 19 cases, memory decline in 12 cases, rage in 9 cases, inattention in 8 cases, unflexible body in 6 cases, two or more symptoms appeared in 15 cases at the same time. Conclusion: Changes of gray matter volume were demonstrated in mild traumatic brain injury patients with voxel-based morphometry method, which may be related to its clinical symptoms.
作者
杨登法
金杭皇
张素娟
杨婷
吴亮
王林友
沈剑敏
余鑫锋
YANG Dengfa;JIN Hanghuang;ZHANG Sujuan;YANG Ting;WU Liang;WANG Linyou;SHEN Jianmin;YU Xinfeng(Department of Radiology, Taizhou Municipal Hospital, Taizhou 318000, China;Department of Neurological Surgery, Taizhou Municipal Hospital, Taizhou 318000, China;Department of Radiology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China)
出处
《温州医科大学学报》
CAS
2019年第7期497-500,共4页
Journal of Wenzhou Medical University
基金
台州市科技计划项目(1501KY22)
台州市医学会计划项目(TZSYXH18-30)
椒江区科技计划项目(142069)
