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Synthesis, Crystal Structure and Fungicidal Activity of 3-(Difluoromethyl)-1-methyl-N-((2-(trifluoromethyl)phenyl) carbamoyl)-1H-pyrazole-4-carboxamide 被引量:2

Synthesis, Crystal Structure and Fungicidal Activity of 3-(Difluoromethyl)-1-methyl-N-((2-(trifluoromethyl)phenyl) carbamoyl)-1H-pyrazole-4-carboxamide
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摘要 The title compound 3-(difluoromethyl)-1-methyl-N-((2-(trifluoromethyl)phenyl)-carbamoyl)-1 H-pyrazole-4-carboxamide(C14 H11 F5 N4 O2) was synthesized, and its structure was confirmed by 1 H NMR, H RMS and X-ray diffraction. It crystallizes in monoclinic system, space group P21/n with a = 6.994(3), b = 13.860(6), c = 15.308(7) ?, β = 97.632(6)°, V = 1470.8(11) ?3,Z = 4, the final R = 0.0692 and wR = 0.2108 for 3989 observed reflections with Ⅰ > 2σ(Ⅰ). The preliminary biological test shows that the title compound has moderate fungicidal activities against Pseudomonas syringae.
作者 SUN Na-Bo ZHAI Zhi-Wen TONG Jian-Ying CAI Peng-Peng HE Fang-Yue HAN Liang LIU Xing-Hai 孙娜波;翟志文;童建颖;蔡彭鹏;何方岳;韩亮;刘幸海(College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China;College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)
出处 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第5期706-712,668,共8页 结构化学(英文)
基金 funded by the Public Science&Technology Project of Zhejiang Province(No.2017C32011) Mid-Youth Academic Team of Zhejiang Shuren University Natural Science Foundation of Zhejiang Province(No.LY19C140002)
关键词 PYRAZOLE ACYL urea SYNTHESIS crystal structure FUNGICIDAL activities pyrazole acyl urea synthesis crystal structure fungicidal activities
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