摘要
目的探讨电化学疗法治疗老年恶性黑色素瘤的临床效果。方法对35例不愿或无法进行手术治疗的老年恶性黑色素瘤患者使用电化学疗法治疗。应用欧洲癌症治疗研究组织生命质量测定量表(EORTCQLQ-C30)对患者治疗前、治疗后6个月的生存质量进行评价。结果35例中完全缓解13例(37.1%),部分缓解16例(45.7%),疾病稳定5例(14.3),疾病进展1例(2.9%),完全缓解+部分缓解率为82.8%,随访1、3、5年生存率分别为74.3%、45.7%和28.6%。EORTCQLQ-C30量表评分治疗前后在身体功能、角色功能、情绪功能、社会功能、物理症状、健康经济相关维度比较差异均有统计学意义(P<0.05),认知功能维度差异无统计学意义(P>0.05)。结论电化学疗法可应用于不愿或无法手术治疗的老年恶性黑色素瘤患者,方法简便安全、创伤小、恢复快,可提高患者的生存质量。
Objective To investigate the clinical effects of electrochemical therapy on malignant melanoma in older people. Methods The electrochemical therapy was used in the treatment of malignant melanoma in 35 older patients who were unwilling or unable to undergone surgery. European organization for research and treatment of cancer core scale ( EORTC QLQ-C30) was used to evaluate the quality of life before and 6 months after treatment. Results Complete remission ( CR), partial remission ( PR), no change ( NC) and progress disease ( PD) were seen in 13 cases (37.1%), 16 cases (45.7%), 5 cases (14.3%) and lease (2.9%), respectively. The rate of CR + PR was 82.8%.1 year, 3 years and 5 years survival rate were 74.3%, 45.7% and 28.6%, respectively. After treatment, EORTC QLQ-C30 score showed that physical function, role function, emotional function, social function, physical symptoms and dimensions related to health economy were significantly improved compared with those before treatment (P< 0.05 ). However, there was no significant difference in cognitive function dimension ( P> 0.05 ). Conclusion Electrochemical therapy is effective in the treatment of malignant melanoma in older patients who are unwilling or unable to undergone surgery. It can improve the quality of life.
作者
曹霞
李翔
张丹
李曾
Cao Xia;Li Xiang;Zhang Dan;Li Zeng(Department of Oncology, 3201 Hospital of Hanzhong, Hanzhong 723000, China)
出处
《国际老年医学杂志》
2019年第3期174-177,共4页
International Journal of Geriatrics
基金
陕西省科学技术研究与发展计划项目(No.2016SF-089)
关键词
电化学疗法
恶性黑色素瘤
临床疗效
生存质量
Electrochemical therapy
Malignant melanoma
Clinical effects
Quality of life
