摘要
糖尿病性心血管疾病是糖尿病患者的慢性并发症之一,其发病机制包括氧化应激的产生、晚期糖基化终末产物和蛋白激酶C(PKC)的激活等。其中,活性氧类的生成增加被认为是导致糖尿病性心血管疾病的核心机制。氧化应激可通过直接或间接激活核因子κB、p38促分裂原活化的蛋白激酶、PKC、肾素-血管紧张素-醛固酮系统等路径,引起炎症、内皮细胞功能障碍、动脉粥样硬化、心肌细胞肥大、凋亡和心肌纤维化,导致严重的心脏功能障碍。未来,深入了解氧化应激在糖尿病性心血管疾病的病理生理机制将为其预防和治疗提供理论依据。
Diabetic cardiovascular disase is one of the chronic complications in diabetic patients.Its pathogenesis include s the production of oxidative stress,the activation of advanced glycation end products and activation of protein kinase C (PKC).Increased production of reactive oxygen species is considered to be the core mechanism leading to diabetic cardiovascular disease.Oxidative stress can induce inflammation,endothelial dysfunction,atherosclerosis,cardialmyocyte hypertrophy ,apoptosis and myocardial fibrosis by directly or indirectly activating nuclear factor κB,p38 mitogen-activated protein kinase ,PKC and renin- angiotensin-aldosterone system,leading to severe cardiac dysfunction.In the future,further understanding of the pathophysiological mechanism of oxidative stress in diabetic cardiovascular disease will provide theore- tical basis for the prevention and treatment.
作者
练淑平
张耀
王振花
LIAN Shuping;ZHANG Yao;WANG Zhenhua(Graduate School,Guangdong Medical University,Zhanjiang 524023,China;Department of Cardiology,Central Hospital of Shenzhen Baoan District,Shenzhen 518102,China;Department of Cardiology,Shenzhen Baoan People′s Hospital,Shenzhen 518101,China)
出处
《医学综述》
2019年第10期2029-2033,共5页
Medical Recapitulate
关键词
糖尿病
心血管疾病
氧化应激
Diabetes mellitus
Cardiovascular disease
Oxidative stress
