摘要
【目的】研究上海市中老年人群2型糖尿病与尿中邻苯二甲酸酯及其代谢产物含量的相关性。【方法】病例组来自上海市某社区医院管理健康档案登记在册,年满50岁及以上,已诊断糖尿病病史>3个月,无严重心脏、肾脏等疾病糖尿病患者;对照组的健康人群来源于复旦大学公共卫生学院2012到2014年进行的“上海市食物消费量调查”项目中的2642名居民,年满50岁及以上,未患糖尿病,且无严重心脏、肾脏等其他疾患。将病例组与对照组通过年龄、性别进行配对,对病例组及对照组尿中邻苯二甲酸酯代谢产物差异进行统计分析。【结果】尿中邻苯二甲酸酯代谢物除邻苯二甲酸单苄基酯(MBzP)和单(2-羧基己基)邻苯二甲酸酯(MCMHP)外,其余代谢物的水平都与糖尿病患病呈相关性(P<0.05),且糖尿病患者尿中邻苯二甲酸酯代谢物水平高于健康人群(OR>1)。其中,邻苯二甲酸单甲酯(MMP)OR值为1.099(1.069,1.130)(P<0.01),邻苯二甲酸单乙酯(MEP)OR值为1.013(1.009,1.017)(P<0.01),邻苯二甲酸单异丁酯(MiBP)OR值为1.066(1.016,1.119)(P<0.01),邻苯二甲酸单正丁酯(MnBP)OR值为1.034(1.021,1.047)(P<0.01),邻苯二甲酸单(2-乙基己基)酯(MEHP)OR值为1.006(1.002,1.010)(P<0.01),MEOHP的OR值为1.074(1.049,1.099),MECPP的OR值为1.013(1.006,1.020)(P<0.01),MEHHP的OR值为1.015(1.008,1.022)(P<0.01)。【结论】邻苯二甲酸酯暴露与中老年2型糖尿病之间可能存在一定的相关性。
[Objective]To investigate the relationship between type 2 diabetes and phthalates in urine and its metabolites in middle and old age people in Shanghai.[Methods]The subjects in the case group were selected from a community in shanghai who registered in a health management file with history of diagnosed diabetes for>3 months and at the age of 50 years or older but without serious heart and kidney diseases.The healthy subjects in the control group were from 2 642 residents in the"Shanghai Food Consumption Survey"project conducted by Fudan University School of Public Health from 2012 to 2014.The candidates were 50 years of age or older,no diabetes,and no serious heart,kidney and other diseases.The case group and the control group were paired by age and sex,and then the differences in urinary phthalate metabolites between case group and control group were statistically analyzed.[Results]The metabolic concentrations of phthalates in urine except MBzP and MCMHP proved to be significantly correlated with diabetes(P<0.05),and are risk factors for diabetes(OR>1).The odds ratio(OR)of MMP was 1.099(1.069,1.130)(P<0.01),OR of MEP was 1.013(1.009,1.017)(P<0.01),OR of MiBP was 1.066(1.016,1.119)(P<0.01),OR of MnBP was 1.034(1.021,1.047)(P<0.01),OR of MEHP was 1.006(1.002,1.010)(P<0.01),OR of MEOHP was 1.074(1.049,1.099)(P<0.01),OR of MECPP was 1.013(1.006,1.020)(P<0.01),OR of MEHHP was 1.015(1.008,1.022)(P<0.01).[Conclusion]It is found there may be some associations between exposure to phthalates and type 2 diabetes in middle and old age.
作者
刘晓虹
周小锋
陈玮华
贾福怀
张梅如
陈婧司
吴岷
陈波
厉曙光
LIU Xiao-hong;ZHOU Xiao-feng;CHEN Wei-hua;JIA Fu-huai;ZHANG Mei-ru;CHEN Jing-si;WU Min;CHEN Bo;LI Shu-guang(Nanjing East Road Community Health Service Center,Huangpu District,Shanghai 200003,China;Key Laboratory of Public Health Safety of Ministry of Education,School of Public Health,Fudan University,Shanghai 200032,China;Ningbo Yofoto Biotechnology Co.,Ltd.,Ningbo,Zhejiang 315012,China)
出处
《上海预防医学》
CAS
2019年第6期443-447,共5页
Shanghai Journal of Preventive Medicine
基金
国家“十三五”重点专项项目(2016YFD0400602)
关键词
中老年
2型糖尿病
邻苯二甲酸酯
middle and old age people
type 2 diabetes
phthalates
