摘要
【目的】探讨芎红活血外洗方手足浸泡方法对卡培他滨化疗后手足综合征(hand-foot syndrome,HFS)的预防作用。【方法】随机将67例接受含卡培他滨化疗的胃肠道恶性肿瘤患者分为2组,实验组(34人)采用基础护理及芎红活血外洗方手足浸泡治疗,对照组(33人)予以基础护理及温水浸泡。使用卡培他滨化疗的同时开始对两组人群予以相应治疗。【结果】实验组HFS发生率显著低于对照组(17.6%与42.4%,P=0.027),且发生时间显著晚于对照组(P=0.032)。对照组患者的手足疼痛症状较实验组患者明显(P=0.002)。是否使用中药浸泡(OR=3.280,P=0.040)是HFS发生的独立危险因素。对照组中,卡培他滨联合紫杉醇患者的HFS发生率,高于卡培他滨联合奥沙利铂的患者(P=0.047)。【结论】芎红活血外洗方手足浸泡对卡培他滨相关性HFS具有很好的预防作用。
[Objective]To investigate the curative effect of early application of the herbal fumigation on hand-foot syndrome(HFS)induced by capecitabine.[Methods]A series of 67 patients with gastrointestinal malignancies receiving capecitabine chemotherapy were randomly divided into two groups.The treatment group(34 patients)was treated with herbal immersion and basic care,while the control group(33 patients)with warm water immersion and basic care.The corresponding treatment was adopted as soon as the chemotherapy with capecitabine was started.[Results]The incidence and occurrence time of HFS in the treatment group were significantly lower(17.6%vs 42.4%,P=0.027)and later(P=0.032)than that in the control group.The symptoms of pain in the control group were more significant than those in the treatment group(P=0.002).Treatment without herbal immersion(OR=3.280,P=0.040)were independently related to HFS.In the control group,the incidence of HFS in patient taking capecitabine and paclitaxel were significantly higher than those taking capecitabine and oxaliplatine(P=0.047).[Conclusion]Herbal immersion has preventive and therapeutic effect on hand-foot syndrome caused by capecitabine.
作者
陆莉
杨柳
LU Li;YANG Liu(Ruijin Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China)
出处
《上海预防医学》
CAS
2019年第6期510-513,共4页
Shanghai Journal of Preventive Medicine
基金
上海交通大学医学院科级基金项目(JYhz1707)
