摘要
目的研究丹参川芎嗪联合无创正压通气(NIPPV)对老年肺心病患者心肺功能及血清N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)和可溶性人基质裂解素2(soluble suppression of tumorigenesis 2,sST2)影响。方法选择2015年6月至2017年6月收治的120例老年肺心病患者,根据随机数字表法分为对照组和观察组,每组60例。其中对照组接受NIPPV治疗,观察组联合使用NIPPV和丹参川芎嗪。比较2组患者治疗后的疗效、治疗前后生活质量,心肺功能和血清sST2、NT-proBNP水平以及不良反应情况。结果观察组治疗总有效率91.67%和中医证候评分有效率(88.33%)均明显高于对照组(78.33%、73.33%),差异有统计学意义(P<0.05)。2组患者治疗后心肺功能指标均显著改善,其中观察的SV、EF、E/A、 FEV1/FVC、 FEV1%指标水平显著高于对照组,EF显著低于对照组(P<0.05)。2组患者治疗后血清sST2、NT-proBNP水平均显著下降,且观察组血清sST2、NT-proBNP水平显著低于对照组(P<0.05)。2组患者经治疗后生理功能、身体疼痛以及总体健康评分均显著增加,其中观察组各评分显著高于对照组(P<0.05)。2组患者治疗期间的不良反应类型和发生率差异无统计学意义(P>0.05)。结论丹参川芎嗪联合NIPPV治疗肺心病疗效显著,能够有效降低血清sST2、NT-proBNP水平,改善心肺功能,从而促进预后以及提高治疗效果和生活质量,值得推广应用。
Objective To investigate the effects of Danshen Ligustrazine combined with non-invasive positive pressure ventilation(NIPPV) on cardiorespiratory function and serum levels of N-terminal pro-brain natriuretic peptide(NT-proBNP) and soluble suppression of tumorigenesis 2(sST2) in elderly patients with pulmonary heart disease(PHD).Methods A total of 120 elderly patients with PHD who were admitted and treated in our hospital from June 2015 to June 2017 were randomly divided into observation group(n=60) and control group(n=60) according to random digital table. The patients in control group were treated by NIPPV,however,the patients in observation group were treated by NIPPV combined with Danshen Ligustrazine.The clinical curative effects, the quality of life,cardiopulmonary function and serum levels of sST2 and proBNP as well as adverse reactions were observed and compared between the two groups before and after treatment.Results After treatment,the clinical total effective rate(91.67%) and the effective rate of TCM syndrome score(88.33%) in observation group were significantly higher than those(78.33% and 73.33%,respectively) in control group(P<0.05).The indexes of cardiac and pulmonary function were significantly improved after treatment in both groups,and the levels of SV,EF,E/A,FEV1/FVC and FEV1% in observation group were significantly higher than those in control group,however, the EF levels were significantly lower than those in control group(P<0.05).After treatment,the serum levels of sST2 and NT-proBNP were significantly decreased in both groups(P<0.05),moreover, the serum levels of sST2 and NT-proBNP in observation group were significantly lower than those in control group(P<0.05).The physiological function,body pain and overall health scores in both groups were significantly increased after treatment,and the scores in observation group were significantly higher than those in control group(P<0.05).In addition there were no significant differences in the type and incidence rate of adverse reactions between the two groups(P>0.05).Conclusion The therapeutic effects of Danshen Ligustrazine combined with NIPPV on PHD are significantly effective,which can effectively reduce the serum levels of sST2 and NT-proBNP,improve cardiopulmonary function,improve patient’s prognosis, therapeutic effects and life quality of patients,thus, which is worth popularizing in clinical practice.
作者
李雪峰
LI Xuefeng(Department of Pharmacy, People’s Hospital of Ba’nan District, Chongqing 401320,China)
出处
《河北医药》
CAS
2019年第11期1614-1617,1622,共5页
Hebei Medical Journal
关键词
丹参川芎嗪
无创正压通气
老年肺心病
可溶性人基质裂解素2
血清N末端脑钠肽前体
Danshen Ligustrazine
non-invasive positive pressure ventilation
senile pulmonary heart disease
soluble suppression of tumorigenesis 2
N-terminal pro-brain natriuretic peptide
