期刊文献+

脑小血管病轻度认知损害与血清炎性因子的相关性 被引量:12

ASSOCIATION BETWEEN MILD COGNITIVE IMPAIRMENT AND SERUM INFLAMMATORY FACTORS IN CEREBRAL SMALL VESSEL DISEASE
下载PDF
导出
摘要 目的探讨脑小血管病(CSVD)轻度认知损害与血清炎性因子相关性。方法CSVD病人100例,其中CSVD不伴认知障碍者和CSVD伴有认知障碍者各50例,同时选取健康体检者50例为健康对照组。采用蒙特利尔认知评估(MoCA)量表及日常生活活动能力(ADL)量表评定CSVD病人认知功能,检测各组受检者血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平。应用Pearson相关系数分析血清炎症因子Hcy、hs-CRP、IL-6和TNF-α水平与CSVD认知功能障碍间的相关性。结果CSVD伴认知障碍组视空间与执行功能、命名、记忆、注意力、语言、抽象能力、定向评分低于健康对照组及CSVD不伴认知障碍组,差异有显著性(F=6.782~10.663,P<0.05);健康对照组、CSVD不伴认知障碍组各项目评分比较,差异无统计学意义(P>0.05)。CSVD伴认知障碍组炎性因子Hcy、hs-CRP、IL-1、TNF-α水平均明显高于健康对照组和CSVD不伴认知障碍组,差异有显著性(F=14.119~20.173,P<0.05);CSVD伴认知障碍组血清Hcy、hs-CRP、IL-1、TNF-α水平与MoCA视空间与执行功能、命名、记忆、注意力、语言、抽象能力、定向评分均有相关性(r=-2.432^-0.039,P<0.05)。结论血清学指标Hcy、hs-CRP、IL-1、TNF-α检测联合MoCA量表和ADL量表评估可以提高CSVD伴有认知功能障碍的诊断效率。 Objective To investigate the association between mild cognitive impairment and serum inflammatory factors in patients with cerebral small vessel disease (CSVD). Methods A total of 100 patients with CSVD were enrolled, among whom 50 had no cognitive impairment and 50 had cognitive impairment, and 50 healthy individuals were enrolled as healthy control group. Montreal Cognitive Assessment (MoCA) and Activity of Daily Life Scale (ADL) were used to evaluate cognitive function in CSVD patients, and the serum levels of homocysteine (Hcy), positive high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) were measured. The Pearson correlation coefficient was used to analyze the correlation of the serum inflammatory factors Hcy, hs-CRP, IL-6, and TNF-α with cognitive impairment in CSVD. Results Compared with the healthy control group and the non-cognitive impairment CSVD group, the cognitive impairment+CSVD group had significantly lower scores of visual space and executive function, naming, memory, attention, language, abstract ability, and orientation ( F =6.782-10.663, P <0.05);there were no significant differences in the scores of each item between the healthy control group and the non-cognitive impairment CSVD group ( P >0.05). The cognitive impairment+CSVD group had significantly higher levels of the inflammatory factors Hcy, hs-CRP, IL-6, and TNF-α than the healthy control group and the non-cognitive impairment CSVD group ( F =14.119-20.173, P <0.05). In the cognitive impairment+CSVD group, serum levels of Hcy, hs-CRP, IL-6, and TNF-α were correlated with the scores of visual space and executive function, naming, memory, attention, language, abstraction ability, and orientation in MoCA ( r =-2.432 to -0.039, P <0.05). Conclusion The serological markers Hcy, hs-CRP, IL-6, and TNF-α combined with MoCA and ADL scales can improve the diagnostic efficiency for CSVD with cognitive impairment.
作者 唐荣盛 邹宏丽 欧爱春 宋玉强 TANG Rongsheng;ZOU Hongli;OU Aichun;SONG Yuqiang(Department of Neurology,Affiliated Hospital of Qingdao University,Qingdao 266003,China)
出处 《青岛大学学报(医学版)》 CAS 2019年第4期415-418,共4页 Journal of Qingdao University(Medical Sciences)
基金 山东省自然科学基金资助项目(ZR2009CM136)
关键词 脑血管障碍 认知功能障碍 炎症趋化因子类 精神状态和痴呆测试 cerebrovascular disease cognitive dysfunction chemokines mental status and dementia tests
  • 相关文献

参考文献13

二级参考文献87

  • 1Xing Li,Da-Xiang Wen,Yan-Hong Zhao,Yan-Nan Hang,M Susan Mandell.Increase of beta-amyloid and C-reactive protein in liver transplant recipients with postoperative cognitive dysfunction[J].Hepatobiliary & Pancreatic Diseases International,2013,12(4):370-376. 被引量:13
  • 2TZOURIO C. Vascular factors and cognition: toward a prevention of dementia[J]? Hypertens Suppl, Z00a, 21 (5) :S15- 19.
  • 3HOOPS S, NAZEM S, SIDEROWF A D, et al. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease[J]. Neurology, 2009,73(21) : 1738-1745.
  • 4ZADIKOFF C, FOX S H, TANG-WAI D F, et al. A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson 's disease[J]. Mov Disord, 2008,23(2) :297-299.
  • 5SMITH T. The Montreal Cognitive Assessment: validity and utility in a memory clinic setting[J]. Can J Psychiatry, 2007, 52(5) : 329-332.
  • 6OLSON R A, CHHANABHIA T, MCKENZIE M. Feasibility study of the Montreal Cognitive Assessment (MoCA) in patients with brain metastases[J]. Support Care Cancer, 2008, 16(11) :1273-1278.
  • 7LUIS C A, KEEGAN A P, MULLAN M. Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the southeastern US[ J]. Int J Geriatr Psychiatry, 2009,24(2) : 197-201.
  • 8NASREDDINE Z S, PHILLIPS N A, BEDIRIAN V, et al. The Montreal Cognitive Assessment, MoCA:a brief screening tool for mild cognitive impairment[J]. Am Geriatr Soc, 2005, 53,695-699.
  • 9NYS G M, VAN ZANDVOORT M J, DE KORT P L, et al. Restrictions of the Mini-Mental State Examination in acute stroke[J]. Arch Clin Neuropsychol, 2005,20(5) :623-629.
  • 10LEE Y, LEE D W, CHO S J, et al. Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment[J]. Geriatr Psychiatry Neurol, 2008,21 (2) : 104-110.

共引文献169

同被引文献113

引证文献12

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部