摘要
目的探讨奥沙利铂联合替吉奥胶囊治疗晚期大肠癌的临床疗效。方法选取本院2012年3月至2016年3月诊治的晚期大肠癌患者40例,采用随机数字表法分为两组,对照组患者20例采用奥沙利铂治疗,观察组患者20例采用奥沙利铂联合替吉奥胶囊治疗,于治疗前后行血清学指标检测,比较两组患者的临床疗效和不良反应。结果两组患者治疗后血清学指标(CEA、AFP、CA19-9、TK1)较治疗前降低(P<0.05)。两组患者治疗后血清学指标(INF-γ、TNF-α、IL-2)较治疗前增加(P<0.05)。观察组患者治疗后血清学指标(CEA、AFP、CA19-9、TK1)低于对照组(P<0.05)。观察组患者治疗后血清学指标(INF-γ、TNF-α、IL-2)高于对照组(P<0.05)。观察组患者总有效率高于对照组(P<0.05)。两组患者不良反应(肝功能异常、胃肠道反应、骨髓抑制、血小板减少、外周神经炎)比较,差异无统计学意义。结论奥沙利铂联合替吉奥胶囊治疗晚期大肠癌的疗效显著且安全性高,值得临床推广使用。
Objective To investigate clinical effect of Oxaliplatin combined with Tego capsule in treatment for advanced colorectal cancer. Methods 40 patients with advanced colorectal cancer were selected in hospital from March 2012 to March 2016, who were divided into two groups by random number table method 20 patients treated Oxaliplatin as control group. 20 patients treated Oxaliplatin combined with Tego capsule as observation group. Serological indexes detected before and after treatment. Clinical effect and adverse reactions were compared between two groups. Results Serological indicators (CEA, AFP, CA19-9, TK1) after treatment decreased in two groups (P<0.05). Serological indicators (INF-γ,TNF-α, IL-2) after treatment increased in two groups (P<0.05). Serological indicators (CEA, AFP, CA19-9, TK1) after treatment in observation group were lower than control group (P<0.05). Serological indicators (INF-γ,TNF-α,IL-2) after treatment in observation group were higher than control group (P< 0.05). Total effective rate in observation group was higher than control group (P<0.05). There were no significant difference in adverse reactions (abnormal liver function, gastrointestinal reaction, myelosuppression, thrombocytopenia, peripheral neuritis) between two groups. Conclusion Oxalipla- tin combined with Tego capsule have significant effect and high safety in treatment for advanced colorectal cancer, which is worthy of clinical application.
作者
高鹏
黄玉树
杨飞
Gao Peng;Huang Yushu;Yang Fei(Department of Pharmacy, Poyang County People' s Hospital, Shangrao City, Jiangxi Province, Shangrao, Jiangxi, 333100, China)
出处
《当代医学》
2019年第18期35-37,共3页
Contemporary Medicine
关键词
奥沙利铂
替吉奥胶囊
晚期大肠癌
Oxaliplatin
Tego capsule
Advanced colorectal cancer
