摘要
炎症性肠病(IBD)是一类高发、病因尚未明确的慢性自身免疫性疾病,在全世界范围内发病率呈上升趋势。肠道微环境稳态失衡、免疫功能失调、环境变化或遗传因素都可能导致疾病的发生。免疫细胞,如巨噬细胞、树突状细胞、固有淋巴细胞以及T细胞、B细胞在IBD中发挥重要作用。巨噬细胞或树突状细胞通过上调炎症细胞因子表达,T细胞、B细胞通过分泌细胞因子或抗体参与IBD免疫调控。阐明IBD免疫作用的机制,可能为IBD的治疗提供新靶点。
Inflammatory bowel disease(IBD) is a type of autoimmune disease with high incidence and unclear etiology.The homeostasis imbalance of the intestinal microenvironment,immune dysfunction,environmental or genetic factors may all contribute to the development of the disease.Immune cells such as macrophages,dendritic cells,innate lymphoid cells,and T cells and B cells,play important roles in IBD.Macrophage or dendritic cells upregulate inflammatory cytokine expression,while T cells and B cells secrete cytokines or antibodies to participate in IBD immunoregulation.Elucidating the mechanism of immune function of IBD may provide new targets for IBD treatment.
作者
陈策
黄功华
刘新光
CHEN Ce;HUANG Gonghua;LIU Xinguang(Institute of Aging Research,Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Guangdong Medical University,Dongguan 523808 China;Institute of Biochemistry & Molecular Biology,Guangdong Medical University,Dongguan 523808,China;Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China)
出处
《医学综述》
2019年第11期2081-2085,2091,共6页
Medical Recapitulate
基金
国家自然科学基金(81671399,81170327)
广东省普通高校创新团队建设项目(2015KCXTD022)
广东省普通高校特色创新类项目(2015KTSCX049)
东莞市国际科技合作(含港澳台)项目(2016508102001)
