摘要
目的分析小剂量左甲状腺素在治疗良性甲状腺结节方面的具体疗效。方法研究对象方便选择该院于2016年1月-2017年12月两年时间内所收治的96例良性甲状腺结节患者,并对其治疗的病历资料展开回顾性分析。在超声检查中使用超声诊断仪观察患者甲状腺两侧叶的结节情况,然后记录大小、数量、回声情况等。如果患者超声检查后发现结节直径在1cm以上或出现钙化点、回声不均的情况时需要采取细针穿刺。给予患者小剂量左甲状腺激素,剂量为25μg,1次/d,治疗周期维持在10个月,观察左甲状腺素治疗前后患者的部分实验室指标变化与甲状腺结节变化,然后对数据结果展开分析。结果该次研究结果显示,在实验室检查指标结果数据的对比方面,患者主要进行了TT4、TSH、TC、HDL、LDL与TG几项指标的检查,其中TT4、HDL、LDL、TG 4项指标差异无统计学意义(t=1.025,0.990,0.753,0.705,P>0.05),但TSH与TC两项指标差异明显,TSH值治疗前为(2.70±0.60)mU/L,治疗后为(2.03±0.48)mU/L;TC值治疗前为(4.22±0.42)mmol/L,治疗后为(3.66±0.51)mmol/L,(t=6.048,5.005,P<0.001),证明了小剂量左甲状腺素治疗对于甲状腺结节的有效性。结论小剂量左甲状腺素在治疗良性甲状腺结节方面具有显著的作用,能够显著改善患者的实验室指标,具有降低血脂的作用,对于某些实性结节患者或TSH水平增高患者来说具有重要的临床应用价值。
Objective To analyze the specific efficacy of low-dose levothyroxine in the treatment of benign thyroid nodules.Methods A total of 96 patients with benign thyroid nodules admitted to our hospital from January 2016 to December 2017 were convenient selected as subjects, and their medical records were retrospectively analyzed. In the ultrasonic examination,the ultrasonic diagnostic instrument was used to observe the nodules on both sides of the thyroid gland, and then the size,quantity and echo were recorded. If the diameter of nodules is more than 1 cm or calcification points or uneven echo were found after ultrasound examination, fine needle puncture should be adopted. Patients were given a small dose of levothyroxine(25 μg) once a day for 10 months. Changes in some laboratory indexes and thyroid nodules before and after levothyroxine treatment were observed, and then the data results were analyzed. Results The results of this study showed that in the comparison of the results of laboratory test indicators, the patients mainly examined TT4, TSH, TC, HDL, LDL and TG indicators, among which TT4, HDL, LDL, TG had no statistical significance(t=1.025, 0.990, 0.753, 0.705, P>0.05). But the difference between TSH and TC was significant. The TSH value was(2.70±0.60) mU/L before treatment, after treatment(2.03±0.48) mU/L;TC value was(4.22±0.42) mmol/L before treatment, and(3.66±0.51) mmol/L after treatment(t=6.048, 5.005, P<0.001). It proved the efficacy of low-dose levothyroxine treatment for thyroid nodules. Conclusion Low-dose levothyroxine has a significant effect in the treatment of benign thyroid nodules, which can significantly improve the laboratory indicators of patients. It has the effect of reducing blood lipids. For some patients with solid nodules or with TSH level increase, it has important clinical application value.
作者
陆继明
LU Ji-ming(General Surgery Liangshan County People's Hospital,Liangshan,Shandong Province,272600 China)
出处
《中外医疗》
2019年第12期116-118,共3页
China & Foreign Medical Treatment
关键词
小剂量
左甲状腺素
良性甲状腺结节
疗效分析
Small dose
Levothyroxine
Benign thyroid nodules
Curative effect analysis
