摘要
目的观察奥氮平联合托烷司琼、地塞米松预防化疗所致恶心呕吐(CINV)的疗效。方法 62例接受高致吐化疗药物治疗的患者,随机分为观察组和对照组,每组31例。观察组患者采用奥氮平联合托烷司琼、地塞米松预防CINV,对照组患者采用托烷司琼、地塞米松预防CINV。比较两组患者急性和延迟性CINV发生情况。结果观察组患者急性CINV发生率为45.16%(14/31),与对照组的67.74%(21/31)比较差异无统计学意义(P>0.05);观察组患者延迟性CINV发生率为48.39%(15/31),低于对照组的80.65%(25/31),差异具有统计学意义(P<0.05)。结论在地塞米松联合托烷司琼预防CINV的基础上增加奥氮平,对延迟性CINV具有较好的预防效果,从而提高肿瘤患者化疗期间的生活质量,增加患者的依从性。
Objective To observe the efficacy of olanzapine combined with tropisetron and dexamethasone in preventing chemotherapy induced nausea and vomiting(CINV). Methods A total of62 patients receiving high-sputum chemotherapeutic drugs were randomly divided into observation group and control group, with 31 cases in each group. The control group was treated with olanzapine combined with tropisetron and dexamethasone in preventing CINV, and the control group was treated with tropisetron and dexamethasone in preventing CINV. The occurrence of acute and delayed CINV in two groups was compared.Results The observation group had no statistically significant difference in incidence of acute CINV as45.16%(14/31), comparing with 67.74%(21/31) in the control group(P>0.05). The observation group had lower incidence of delayed CINV as 48.39%(15/31) than 80.65%(25/31) in the control group, and the difference was statistically significant(P<0.05). Conclusion Adding olanzapine on the basis of dexamethasone combined with tropisetron to prevent CINV has better preventive effect on delayed CINV, thus improving the quality of life of cancer patients during chemotherapy and increasing their compliance.
作者
吴丽仙
庞华春
傅健
邝佩霞
黄伟芹
WU Li- xian;PANG Hua- chun;FU Jian(Department of Pharmacy, Xinxing County People' s Hospital, Yunfu 527400, China)
出处
《中国实用医药》
2019年第15期73-74,共2页
China Practical Medicine
基金
云浮市医学科学技术研究项目(项目编号:2017B60)
关键词
奥氮平
托烷司琼
地塞米松
化疗所致恶心呕吐
Olanzapine
Tropisetron
Dexamethasone
Chemotherapy induced nausea and vomiting
