摘要
羧甲基壳聚糖水溶液在一定转速下分散在石蜡油中可形成油包水结构,通过加入碳酸钙体系的交联剂可形成不溶于水的交联微球,将微球分离干燥得到羧甲基壳聚糖的交联粉末,可作为止血粉使用。分别使用GDL/碳酸钙和柠檬酸/碳酸钙复合体系制备羧甲基壳聚糖凝胶微球,其中,柠檬酸可在水热环境下原位还原硝酸银,一步法直接制备含银羧甲基壳聚糖微。结果表明,GDL/碳酸钙和柠檬酸/碳酸钙均可形成微米级的羧甲基壳聚糖凝胶微球。使用柠檬酸/碳酸钙可制备含银的羧甲基壳聚糖凝胶微球,纳米银的紫外吸收峰出现在445 nm处,为纳米级。
The aqueous solution of CMCS was dispersed in paraffin oil at a certain rotation speed to form a water-in-oil structure.The cross-linking microspheres can be formed by adding crosslinking agent into the emulsion.The microspheres are separated and dried subsequently in a certain environment and CMCS powder was obtained and it can be used as a hemostatic powder.CMCS microspheres were prepared with GDL/CaCO3 and citric acid/CaCO3,separately.The in-situ silver reduction CMCS microspheres was prepared by citric acid in one-step method because citric acid has the reducibility to silver nitrate in hydrothermal environment.The results showed that both GDL/CaCO3 and citric acid/CaCO3 can form micron-sized CMCS hydrogel microspheres and nano silver-containing CMCS gel microspheres can be prepared by using citric acid/CaCO3.The ultraviolet absorption peak of nano-silver in the powder appears at 445 which means the silver in the powder is in a nanoscale.
作者
阚广乾
秦荣基
盖文龙
江晓泽
孙宾
Kan Guangqian;Qin Rongji;Gai Wenlong;Jiang Xiaoze;Sun Bin(College of Materials Science and Engineering,Donghua University,Shanghai 201620,China;Shandong Luhai Lansheng Biotechnology Co.,Ltd.,Dongying 257500,China)
出处
《山东化工》
CAS
2019年第9期77-80,共4页
Shandong Chemical Industry
关键词
羧甲基壳聚糖
原位交联
纳米银
凝胶微球
carboxymethyl chitosan
in-situ crosslinking
silver nanoparticles
gel microspheres
