摘要
目的探究生长抑素联合奥美拉唑治疗急性胰腺炎疗效及对患者D-乳酸、外周血二胺氧化酶(DAO)、炎性因子的影响。方法100例急性胰腺炎患者依据随机数字表法分为对照组和观察组,每组50例。对照组患者给予常规治疗;观察组在常规治疗基础上予以生长抑素联合奥美拉唑治疗。比较两组患者治疗后疗效,并检测两组治疗前后D-乳酸、DAO、炎症因子水平变化。结果治疗后,观察组治疗总有效率90.00%,明显高于对照组68.00%,差异有统计学意义(χ^2=7.29,P<0.05)。两组治疗前D-乳酸、DAO水平、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)比较,差异均无统计学意义(t分别=0.58、0.06、0.32、0.17、0.19,P均>0.05)。与对照组治疗后比较,观察组治疗后的D-乳酸、DAO水平、IL-6、TNF-α、CRP水平明显更低,差异有统计学意义(t分别=3.84、12.02、7.71、7.35、19.52,P均<0.05)。结论生长抑素联合奥美拉唑治疗胰腺炎具有较好的临床疗效,可有效促进患者临床症状的恢复,控制炎症的发展,对改善患者预后具有积极的作用。
Objective To explore the effect of somatostatin combined with omeprazole on acute pancreatitis and its influence on D-lactic acid,diamine oxidase(DAO)and inflammatory factors in patients with acute pancreatitis.Methods Totally 100 patients with acute pancreatitis were divided into control group and observation group according to random number table method,50 cases in each group.Patients in the control group were given routine treatment,while patients in the observation group were given somatostatin combined with omeprazole on the basis of routine treatment.The curative effect of the two groups was compared after treatment,and the levels of D-lactic acid,DAO and inflammatory factors were detected before and after treatment.Results After treatment,the total effective rate of the observation group was 90.00%,which was significantly higher than that of the control group(68.00%).The difference was statistically significant(χ^2=7.29,P<0.05).There was no significant difference in D-lactic acid,DAO,IL-6,TNF-α and CRP between the two groups before treatment(t=0.58,0.06,0.32,0.17,0.19,P>0.05).Compared with the control group,the levels of D-lactic acid,DAO,IL-6,TNF-α and CRP of the observation group were significantly lower after treatment(t=3.84, 12.02,7.71,7.35,19.52,P<0.05).Conclusion Somatostatin combined with omeprazole in the treatment of pancreatitis has good clinical efficacy with promoting the recovery of clinical symptoms,controlling the development of inflammation, and improving the prognosis of patients.
作者
徐超
吴月福
杜平
XU Chao;WU Yuefu;DU Ping(Department of Surgery,The Second People's Hospital of Chun'an,Hangzhou 311917,China)
出处
《全科医学临床与教育》
2019年第6期529-531,共3页
Clinical Education of General Practice
