摘要
目的评价颈动脉超声造影检查益气通络方在冠状动脉粥样硬化性心脏病合并颈动脉粥样硬化斑块治疗中的临床效果。方法将60例气虚痰瘀型冠心病合并颈动脉粥样硬化病人,分为治疗组(32例)和对照组(28例)。对照组给予常规西医治疗,治疗组在常规西医治疗基础上加用益气通络方,疗程均为6个月。分别于治疗前后行颈动脉超声造影及血清学检查,观察颈动脉斑块增强峰值强度(iMAX)、达峰时间(RT)、平均渡越时间(mTT)、颈动脉内-中膜厚度(IMT)、斑块厚度及面积和总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)值。结果治疗后治疗组iMAX较对照组下降,RT较对照组延长,差异均有统计学意义(P<0.05);治疗后治疗组IMT低于对照组(P<0.05)。结论益气通络方可有效调控气虚痰瘀型冠心病合并颈动脉粥样硬化病人的斑块的发展,具有稳定颈动脉粥样硬化斑块的作用。
Objective To evaluate the clinical value of Yiqi Tongluo recipe in the treatment of coronary heart disease (CHD)patients with unstable plaque by carotid artery contrast-enhanced ultrasound(CEUS). Methods Sixty cases patients with CHD of Qi deficiency phlegm stasis syndrome(QDPSS) with carotid atherosclerosis were divided into treatment group ( n =32) and control group ( n =28). The control group was given routine western medicine treatment.The treatment group was given Yiqi Tongluo recipe on the basis of routine western medicine treatment for 6 months.The carotid artery CEUS and serological tests were performed before and after treatment respectively.The indexes included carotid plaque enhancement peak intensity (iMAX),peak time (RT),mean transit time (mTT),carotid intima-media thickness(IMT),plaque thickness,area,and total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),and high density lipoprotein cholesterol (HDL-C). Results After treatment,the levels of iMAX and LDL-C were decreased in the treatment group,and RT was prolonged in the treatment group than those in the control group( P <0.05);Compared with those before treatment,the levels of iMAX,IMT,TC,TG,and LDL-C in the treatment group were decreased,the levels of RT,and HDL-C in the treatment group were increased ( P <0.05).The levels of TC,TG,and LDL-C in control group decreased compared with that before treatment ( P <0.05),but there was no significant difference in iMAX,RT,mTT,IMT,plaque thickness,area,and HDL-C before and after treatment ( P >0.05). Conclusion Yiqi Tongluo recipe can effectively regulate blood lipid levels in patients with coronary heart disease of QDPSS with carotid atherosclerosis,and has the effect of stabilizing carotid atherosclerotic plaque.
作者
王骕
董耀荣
沈睿
冯其茂
WANG Su;DONG Yaorong;SHEN Rui;FENG Qimao(Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《中西医结合心脑血管病杂志》
2019年第10期1448-1452,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
上海市科委引导项目(No.15401931000)
上海市进一步加快中医药事业发展三年行动计划项目(No.ZY3-CCCX-3-3024)
上海市自然科学基金项目(No.13ZR1439900)
中国博士后科学基金面上项目(No.2014M550131)
上海市卫生计生系统重要薄弱学科建设中医老年病学学科建设项目(No.2015ZB0504)
上海市中医医院优秀青年人才项目(No.20140006)
