摘要
偏头痛(migraine)表现为单侧搏动性头痛的反复发作,一般持续4~72 h,和(或)伴有先兆症状,如恶心呕吐、畏光及畏声等。病程中每月发作超过15次且每次发作时间超过3个月的偏头痛被称为慢性偏头痛(chronic migraine,CM)。A型肉毒毒素(botulinum toxin type A,BoNT A)作为神经毒素,除了应用于神经肌肉等疾病外,还显示出治疗慢性偏头痛的疗效。目前BoNT A广泛用于慢性偏头痛治疗,但其镇痛机制尚不明确。本文通过对现有BoNT A治疗慢性偏头痛镇痛机制的文献综述,阐明其缓解慢性偏头痛机制的研究进展,以便进一步指导治疗。
Migraine is a recurrent episode of unilateral pulsatile headache,usually lasting 4 to 72 hours,and/or accompanied by aura symptoms such as nausea and vomiting,photophobia and phobia.A migraine that has more than 15 episodes per month and more than 3 months per episode is called chronic migraine (CM).Botulinum toxin type A (hereinafter referred to as BoNT A) is a neurotoxin.In addition to its application to neuromuscular and other diseases,it also shows the efficacy of treating chronic migraine.At present,BoNT A is widely used in the treatment of chronic migraine,but the mechanism of analgesia is not clear.In this paper,through the literature review of the existing BoNT A treatment mechanism of chronic migraine analgesia,the research progress of the mechanism of relieving chronic migraine is elucidated to further guide the treatment.
作者
赵士杰
任占秀
何秋
ZHAO Shijie;REN Zhanxiu;HE Qiu(Graduate School of Dalian Medical University,Dalian 116014,China;Department of Neurology,Liaoning Province Hospital,Shenyang110016,China)
出处
《中国实用神经疾病杂志》
2019年第11期1265-1270,共6页
Chinese Journal of Practical Nervous Diseases
关键词
A型肉毒素
慢性偏头痛
神经递质
外周及中枢系统敏感化
跨突触转运
神经源性炎症
Botulinum toxin type A
Chronic migraine
Neurotransmitter
External and Central system sensitization
Transsynaptic transport
Neurogenic inflammation
