摘要
目的观察单相抑郁障碍患者和双相抑郁障碍患者的睡眠特征以及其认知功能的差异。方法选取2015 02—2016 10茂名市第三人民医院院就诊的单相抑郁障碍患者73例(单相组)、双相抑郁障碍患者76例(双相组),以及同期的健康志愿者60例(对照组)。采用多导睡眠监测系统对受试者的睡眠特征进行监测比较,采用改良过的韦氏成人智力量表(Wechsler Adult Intelligence Scale,WAIS)评定受试者的语言智商、操作智商和总智商;采用韦克斯勒成人记忆量表(Wechsler memory scale,WMS)评定受试者的记忆能力;采用功能失调性态度问卷(Dysfunctional attitudes scales,DAS)评估认知结构。结果 3组受试者的多导睡眠监测指标中,除第2期睡眠时间/比例和快速动眼期睡眠时间/比例外,其他指标差异均有统计学意义( P <0.05)。单相组与双相组患者在总睡眠时间、觉醒时间、觉醒次数、睡眠潜伏期、第1期时间/比例和第3期时间/比例中,差异均有统计学意义( P <0.05)。3组患者WAIS和WMS评分比较,差异有统计学意义( P <0.05)。单相组和双相组在总智商和记忆商数比较中,差异有统计学意义( P <0.05),但2组的语言智商和操作智商比较,差异无统计学意义( P >0.05)。3组受试者DAS评分差异存在统计学意义,双相组显著高于单相组( P <0.05)。其中强制性、依赖性、认知哲学方面,双相组的评分显著高于单相组( P <0.05);但2组患者的脆弱性、吸引和排斥、完美性、寻求赞许及自主性态度方面比较,差异无统计学意义( P >0.05)。结论 单相抑郁障碍和双相抑郁障碍患者均存在睡眠进程和睡眠结构紊乱的问题,认知能力也受到一定程度的损伤,其中双相抑郁患者更为严重。
Objective To observe difference of sleep patterns and cognitive impairment in patients with unipolar or bipolar depression. Methods A total of 73 patients with unipolar depression (Unipolar group),76 patients with bipolar depression (Bipolar group) and 60 health volunteers from February 2015 to October 2016 in our hospital were involved in this study.Polysomnography (PSG) was employed to measure their sleep patterns.Wechsler adult intelligence scale (WAIS) and Wechsler memory scale (WMS) and Dysfunctional attitudes scales (DAS) were applied to assess cognitive function and cognitive structure. Results There was significant difference of sleeping time,sleep latency,duration of wake,sleep efficiency and the proportion of S1 and S3 sleep between three groups ( P <0.05).Patients in the bipolar group had shorter sleeping time,longer sleep latency,shorter duration of wake,poorer sleep efficiency,less number of wake,decreased proportion of S1 sleep and increased proportion of S3 sleep when compared to those in the unipolar group ( P <0.05).Obvious different WAIS and WMS scores were seen between three groups ( P <0.05).Patients in the bipolar group had lower scores of total intelligency and memory than in the unipolar group ( P <0.05).There was significant difference in DAS scores among three groups and DAS scores in the bipolar group was significantly higher than it in the unipolar group ( P >0.05).In terms of coerciveness,dependence,and cognitive philosophy,its sores in the bipolar group were obviously higher than it in the unipolar group ( P >0.05).But there was no significant difference in scores of vulnerability,attraction and rejection,perfectionism,approval seeking and autonomy between the unipolar group and the bipolar group ( P >0.05). Conclusion Patients with both unipolar depression and bipolar depression have sleep disorders and cognitive impairment,patients with bipolar depression are worse.
作者
龚世灵
GONG Shiling(Third People's Hospital of Maoming,Maoming 525200,China)
出处
《中国实用神经疾病杂志》
2019年第8期836-841,共6页
Chinese Journal of Practical Nervous Diseases
